Many patients with acute lymphoblastic leukemia (ALL) show relapse post-chemotherapy. Therefore, it is important to develop a human induced pluripotent stem cell (hiPSC) line from ALL cells to verify the pathophysiology. However, the low efficiency of the established reprogramming protocol has hampered the development of ALL hiPSC lines. Our recently reported novel reprogramming method, using human placenta-derived cell conditioned medium (hPCCM), offers a relatively higher efficiency in humanized conditions. Here, we generated an hiPSC line from ALL-derived CD34+ bone marrow cells, using hPCCM for reprogramming. This hiPSC line might be a useful model for studies on ALL.

许多急性淋巴细胞白血病（ALL）患者在化疗后出现复发。因此，重要的是从ALL细胞开发人诱导的多能干细胞（hiPSC）系以验证病理生理学。但是，已建立的重编程协议的低效率阻碍了所有hiPSC系的开发。我们最近报道的使用人胎盘来源的细胞条件培养基（hPCCM）的新型重编程方法在人源化条件下提供了相对较高的效率。在这里，我们使用hPCCM进行重编程，从ALL来源的CD34 +骨髓细胞生成了hiPSC系。此hiPSC系列可能是研究ALL的有用模型。