Many patients with acute lymphoblastic leukemia (ALL) show relapse post-chemotherapy. Therefore, it is important to develop a human induced pluripotent stem cell (hiPSC) line from ALL cells to verify the pathophysiology. However, the low efficiency of the established reprogramming protocol has hampered the development of ALL hiPSC lines. Our recently reported novel reprogramming method, using human placenta-derived cell conditioned medium (hPCCM), offers a relatively higher efficiency in humanized conditions. Here, we generated an hiPSC line from ALL-derived CD34+ bone marrow cells, using hPCCM for reprogramming. This hiPSC line might be a useful model for studies on ALL.

许多急性淋巴细胞白血病（ALL）患者在化疗后出现复发。因此，从 ALL 细胞中开发人类诱导多能干细胞 (hiPSC) 系以验证病理生理学非常重要。然而，已建立的重编程方案的低效率阻碍了所有 hiPSC 系的开发。我们最近报道的新型重编程方法，使用人胎盘来源的细胞条件培养基（hPCCM），在人源化条件下提供了相对更高的效率。在这里，我们使用 hPCCM 进行重编程，从 ALL 衍生的 CD34+ 骨髓细胞中生成了 hiPSC 系。该 hiPSC 系可能是 ALL 研究的有用模型。