Background

Molybdenum, as a trace element, has various pharmacological effects, including antioxidant, antiviral, anti-allergic, anti-osteoporosis, anti-tumor, anti-inflammatory, anti-diabetic, anti-obesity, and free radical-scavenging activities. This study aimed at investigating the sodium molybdate impacts on cadmium chloride (CdCl₂)-induced testicular toxicity in adult Wistar rats.

Methods

The impacts of oral administration of sodium molybdate (0.05, 0.1, 0.2, and 0.4 mg/kg) was evaluated in healthy and infertile animals. Animals were randomly assigned to nine groups, including healthy control, sodium molybdate alone, infertile control (3 mg/kg of CdCl₂), and sodium molybdate plus CdCl₂. Following 30 days of administration, animals were sacrificed for biochemical and histopathological assays.

Results

The results indicated that administration of sodium molybdate to infertile rats significantly mitigated the cadmium impacts on sperm appearance, concentration, and motility parameters. Also, sodium molybdate reduced the production of malondialdehyde (MDA) and enhanced antioxidant enzymes activities in the testicular homogenates in rats; these findings were supported by histopathological examinations. Treatment with sodium molybdate significantly increased aquaporin-9 (AQP9) expression in the testicular tissues of infertile rats.

Conclusions

The current findings suggested that sodium molybdate performs as a strong protective agent from CdCl₂-related testicular toxicity in rats.

中文翻译：

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钼酸钠对成年雄性 Wistar 大鼠镉相关睾丸损伤的影响。

背景

钼作为一种微量元素，具有多种药理作用，包括抗氧化、抗病毒、抗过敏、抗骨质疏松、抗肿瘤、抗炎、抗糖尿病、抗肥胖、清除自由基等。本研究旨在调查钼酸钠对氯化镉 (CdCl ₂ ) 诱导的成年 Wistar 大鼠睾丸毒性的影响。

方法

在健康和不育动物中评估了口服钼酸钠（0.05、0.1、0.2 和 0.4 mg/kg）的影响。动物被随机分配到九组，包括健康对照、单独的钼酸钠、不育对照（3mg/kg CdCl ₂）和钼酸钠加CdCl ₂。给药30天后，处死动物进行生化和组织病理学测定。

结果

结果表明，给不育大鼠服用钼酸钠可显着减轻镉对精子外观、浓度和运动参数的影响。此外，钼酸钠减少了丙二醛 (MDA) 的产生并增强了大鼠睾丸匀浆中的抗氧化酶活性；这些发现得到了组织病理学检查的支持。钼酸钠处理显着增加了不育大鼠睾丸组织中水通道蛋白 9 (AQP9) 的表达。

结论

目前的研究结果表明，钼酸钠是一种强效保护剂，可以防止大鼠中CdCl ₂相关的睾丸毒性。