Silibinin (SBN), the major active constituent of milk thistle seeds indicated in liver conditions, has low oral bioavailability due to low solubility and degradation in gastric fluid. Hybrid mesoporous silica nanocomposites composed of polymerized alkyl methacrylate monomers (methyl methacrylate, butyl methacrylate or 1:1 mixture of methyl methacrylate and acrylic acid) were developed to enhance dissolution and antioxidant activity of SBN. Samples were worked up by calcination in oven or refluxing with ammonium nitrate. DLS, FE-SEM, AFM, TGA, FTIR, EDS, XRD and BET techniques were employed to characterize unloaded and SBN-loaded particles. Well-tuned hybrid nanoparticles exhibited spherical morphology, small size (~20 nm), large pore volumes (1.6 cm³g⁻¹), high polymer functionality (~50%) and high SBN loading (19%). Importantly, in-vitro dissolution and DPPH antioxidant activity of SBN in acidic gastric medium increased remarkably after loading in the particles. Conclusively, well-tuned hybrid nanocomposites are suggested for modulating the oral bioavailability of poorly sluble phytochemicals.

水飞蓟宾（SBN）是在肝脏条件下出现的水飞蓟种子的主要活性成分，由于其在胃液中的溶解度低和降解，口服生物利用度低。开发了由甲基丙烯酸烷基酯单体（甲基丙烯酸甲酯，甲基丙烯酸丁酯或甲基丙烯酸甲酯和丙烯酸的1：1混合物）组成的杂化介孔二氧化硅纳米复合材料，以增强SBN的溶解性和抗氧化活性。通过在烤箱中煅烧或与硝酸铵回流来对样品进行后处理。采用DLS，FE-SEM，AFM，TGA，FTIR，EDS，XRD和BET技术表征未加载和SBN加载的颗粒。调谐良好的杂化纳米颗粒表现出球形形态，小尺寸（〜20 nm），大孔体积（1.6 cm ³ g ^-1）），高聚合物官能度（约50％）和高SBN含量（19％）。重要的是，SBN在酸性胃介质中的体外溶解和DPPH抗氧化活性在装入颗粒后显着增加。结论是，建议将调优的杂化纳米复合材料用于调节难溶性植物化学物质的口服生物利用度。