Small cell lung cancer (SCLC) is highly heterogeneous. In this issue of Cancer Cell, Ireland et al. demonstrate that MYC mediates neuroendocrine cell plasticity in SCLC by activating NOTCH signaling. This MYC-NOTCH axis controls the dynamic behavior of tumor cells, resulting in the co-existence of SCLC subtypes within individual tumors.

中文翻译：

---

通知您通常的怀疑：MYC负责控制小细胞肺癌的神经内分泌细胞命运。

小细胞肺癌（SCLC）具有高度异质性。在本期《癌细胞》中，爱尔兰等人。证明MYC通过激活NOTCH信号介导SCLC中神经内分泌细胞的可塑性。该MYC-NOTCH轴控制肿瘤细胞的动态行为，从而导致单个肿瘤内SCLC亚型的共存。