Lysosome is a ubiquitous acidic organelle fundamental for the turnover of unwanted cellular molecules, particles, and organelles. Currently, the pivotal role of lysosome in regulating cell death is drawing great attention. Over the past decades, we largely focused on how lysosome influences apoptosis and autophagic cell death. However, extensive studies showed that lysosome is also prerequisite for the execution of regulated necrosis (RN). Different types of RN have been uncovered, among which, necroptosis, ferroptosis, and pyroptosis are under the most intensive investigation. It becomes a hot topic nowadays to target RN as a therapeutic intervention, since it is important in many patho/physiological settings and contributing to numerous diseases. It is promising to target lysosome to control the occurrence of RN thus altering the outcomes of diseases. Therefore, we aim to give an introduction about the common factors influencing lysosomal stability and then summarize the current knowledge on the role of lysosome in the execution of RN, especially in that of necroptosis, ferroptosis, and pyroptosis.

溶酶体是普遍存在的酸性细胞器，其是不需要的细胞分子，颗粒和细胞器更新的基础。目前，溶酶体在调节细胞死亡中的关键作用引起了极大的关注。在过去的几十年中，我们主要关注溶酶体如何影响细胞凋亡和自噬细胞死亡。但是，广泛的研究表明，溶酶体也是进行调节性坏死（RN）的前提。已经发现了不同类型的RN，其中最深入的研究是尸检，坏死性肥大和发烧。靶向RN作为治疗干预已成为当今的热门话题，因为它在许多病理/生理环境中很重要，并且会导致多种疾病。靶向溶酶体以控制RN的发生从而改变疾病的结果是有希望的。因此，我们旨在介绍影响溶酶体稳定性的常见因素，然后总结有关溶酶体在RN实施中，尤其是在尸体坏死，肥大症和烧伤中的作用的当前知识。