Objective

To examine whether urine kynurenine (KYN) levels were associated with early-stage Parkinson’s disease (PD), as well as the value of urine KYN as a potential biomarker in early-stage PD.

Method

Eighty-two participants including 41 PD patients and 41 healthy controls were enrolled into this study. Urine KYN levels were measured with a KYN enzyme-linked immunoassay kit. In order to explore the correlation between some clinical parameters and urine KYN, the clinical parameters for these participants were recorded. Diagnostic value and clinical relevance of urine KYN were assessed by using receiver operator characteristic (ROC) curve and correlation analysis.

Results

Urine KYN levels were significantly higher in the PD group than in the healthy group (891.95 ± 276.65 pg/ml vs. 640.11 ± 122.37 pg/ml, p = 0.000). The correlations between urine KYN levels and clinical parameters are as follows: Hoehn-Yahr stage (r = 0.676, p = 0.000), disease duration (r = 0.772, p = 0.000), Mini-Mental State Examination scores (r = −0.434, p = 0.005). There was no statistically significant correlation between urine KYN with age, low-density cholesterol (LDL), triglycerides (TG), cholesterol (TC), homocysteine (HCY), uric acid (UA), and glomerular filtration rate (GFR). The ROC analysis showed that urine KYN optimal cutoff value of 751.88 pg/ml had a sensitivity of 65.9% and a specificity of 90.2% for distinguishing between PD and controls, with an area under the curve (AUC) of 0.776.

Conclusion

Urine KYN were significantly associated with PD severity and mild cognitive impairment. Urine KYN may be a new biomarker for early-stage PD.

中文翻译：

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尿犬尿氨酸作为帕金森氏病的生物标志物。

目的

检查尿液犬尿氨酸（KYN）水平是否与早期帕金森氏病（PD）有关，以及尿液KYN作为早期PD潜在生物标志物的价值。

方法

包括41位PD患者和41位健康对照者在内的82位参与者参加了这项研究。尿液KYN水平用KYN酶联免疫测定试剂盒测量。为了探讨某些临床参数与尿液KYN的相关性，记录了这些参与者的临床参数。尿KYN的诊断价值和临床意义通过使用接收者操作员特征（ROC）曲线和相关分析进行评估。

结果

PD组的尿KYN水平显着高于健康组（891.95±276.65 pg / ml与640.11±122.37 pg / ml，p  = 0.000）。尿液KYN水平与临床参数之间的相关性如下：Hoehn-Yahr分期（r  = 0.676，p  = 0.000），疾病持续时间（r  = 0.772，p  = 0.000）， 轻度精神状态检查成绩（r = -0.434 ，p = 0.005）。尿KYN与年龄，低密度胆固醇（LDL），甘油三酸酯（TG），胆固醇（TC），高半胱氨酸（HCY），尿酸（UA）和肾小球滤过率（GFR）之间无统计学意义的相关性。ROC分析显示，尿KYN最佳截断值751.88 pg / ml，区分PD和对照的敏感性为65.9％，特异性为90.2％，曲线下面积（AUC）为0.776。

结论

尿KYN与PD严重程度和轻度认知障碍显着相关。尿KYN可能是早期PD的新生物标志物。