Genetic heritability (h²) of alcohol use is reported to be greater in rural dwellers, distressed marriages, low socioeconomic status, in girls who are unmarried or lacking closeness with their parents or religious upbringing, in less-educated men, and in adolescents with peers using alcohol. However, these are all risk factors for heavy drinking, and the greater heritability could be due to quantile-dependent expressivity, i.e., h² dependent upon whether the phenotype (alcohol intake) is high or low relative to its distribution. Quantile regression showed that h² estimated from the offspring-parent regression slope increased significantly from lowest to highest gram/day of alcohol consumption (0.006 ± 0.001 per percent, P = 1.1 × 10⁻⁷). Heritability at the 90th percentile of the sample distribution (0.557 ± 0.116) was 4.5-fold greater than at the 10th percentile (0.122 ± 0.037). Heritabilities for intakes of other macronutrients were not quantile-dependent. Thus quantile-dependent expressivity may explain the higher estimated heritability associated with risk factors for high alcohol consumption.

据报道，酒精使用的遗传遗传率 ( h ² ) 在农村居民、婚姻困境、社会经济地位低下、未婚或与父母或宗教教养缺乏亲密关系的女孩、受教育程度较低的男性和青少年使用酒精的同龄人。然而，这些都是大量饮酒的危险因素，更大的遗传力可能是由于分位数依赖的表现力，即h ² 取决于表型（酒精摄入量）相对于其分布是高还是低。分位数回归表明h ²从后代-父母回归斜率估计，从最低到最高的酒精消耗量（0.006 ± 0.001/%，P = 1.1 × 10 ^-7）显着增加。样本分布第 90 个百分位数 (0.557 ± 0.116) 的遗传力是第 10 个百分位数 (0.122 ± 0.037) 的 4.5 倍。摄入其他常量营养素的遗传力不依赖于分位数。因此，分位数依赖的表现力可以解释与高酒精消费风险因素相关的较高估计遗传力。