Long-term using continuous flow ventricular assist devices could trigger complications associated with diminished pulsatility, such as valve insufficiency and gastrointestinal bleeding. One feasible solution is to produce pulsatile flow assist with speed regulation in continuous flow ventricular assist devices. A third-generation blood pump with pulsatile operation control algorithm was first characterized alone under pulsatile mode at various speeds, amplitudes, and waveforms. The pump was then incorporated in a Mock circulation system to evaluate in vitro hemodynamic effects when using continuous and different pulsatile operations. Pulsatility was evaluated by surplus hemodynamic energy. Results showed that pulsatile operations provided sufficient hemodynamic assistance and increased pulsatility of the circulatory system (53% increment), the mean aortic pressure (65% increment), and cardiac output (27% increment). The pulsatility of the system under pulsatile operation support was increased 147% compared with continuous operation support. The hemodynamic performance of pulsatile operations is susceptible to phase shifts, which could be a tacking angle for physiological control optimization. This study found third-generation blood pumps using different pulsatile operations for ventricular assistance promising.

长期使用连续流动心室辅助装置可能引发与搏动减弱相关的并发症，例如瓣膜功能不全和胃肠道出血。一种可行的解决方案是在连续流心室辅助装置中产生具有速度调节的脉动流辅助。具有脉动操作控制算法的第三代血泵首先在不同速度、幅度和波形的脉动模式下单独表征。然后将泵结合到模拟循环系统中，以评估使用连续和不同脉动操作时的体外血液动力学效果。搏动性通过过剩的血流动力学能量进行评估。结果表明，搏动手术提供了足够的血流动力学辅助，并增加了循环系统的搏动性（增加了 53%），平均主动脉压（65% 增量）和心输出量（27% 增量）。脉动操作支撑下系统脉动较连续操作支撑提高147%。脉动操作的血液动力学性能容易受到相移的影响，这可能是生理控制优化的一个主攻角。这项研究发现使用不同脉动操作的第三代血泵进行心室辅助很有希望。