Identification of compounds active against quiescent artemisinin-resistant Plasmodium falciparum parasites via the quiescent-stage survival assay (QSA).,Journal of Antimicrobial Chemotherapy

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Identification of compounds active against quiescent artemisinin-resistant Plasmodium falciparum parasites via the quiescent-stage survival assay (QSA).
Journal of Antimicrobial Chemotherapy ( IF 3.9 ) Pub Date : 2020-07-12 , DOI: 10.1093/jac/dkaa250
Thibaud Reyser _{1,

2} , Lucie Paloque _{1,

2} , Manel Ouji _{1,

2} , Michel Nguyen _{1,

2} , Sandie Ménard ₃ , Benoit Witkowski ₄ , Jean-Michel Augereau _{1,

2} , Françoise Benoit-Vical _{1,

2,

5}

Affiliation

Quiescence is an unconventional mechanism of Plasmodium survival, mediating artemisinin resistance. This phenomenon increases the risk of clinical failures following artemisinin-based combination therapies (ACTs) by slowing parasite clearance and allowing the selection of parasites resistant to partner drugs.

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