Abstract Hydrogen peroxide (H2O2) is an important product generated in the body and related to many pathophysiological processes and glucose metabolism disorder can cause many fatal diseases in living bodies. Therefore, the sensing of H2O2 and glucose is of great significance in disease diagnostics and treatment. Fluorescent carbon dots (CDs) are one new class of nanoprobes for H2O2 and glucose. Nevertheless, the CD-based sensor is always based on its fluorescence response, which is influenced by the auto-fluorescent interference. Herein, efficient fluorescent CDs were synthesized by one-pot solvothermal method, and the CDs exhibit bright and persistent deep-red (DR) chemiluminescence (CL) in bis(2,4,6-trichlorophenyl) oxalate and H2O2 solution with a CL quantum yield of (8.22 ± 0.30) × 10−3, which is amongst the highest values in ever reported nanomaterials for chemical analysis. Employing the CDs as CL nanoprobes, sensitive sensing for H2O2 has been achieved with a detection limit of 11.7 μM, and further for glucose detection with a detection limit of 12.6 μM. The DR CL CDs is promising to be applied in blood glucose analysis or in vivo biosensor.

中文翻译：

---

化学发光碳纳米点作为过氧化氢和葡萄糖的传感器

摘要 过氧化氢（H2O2）是人体内产生的重要产物，与多种病理生理过程有关，糖代谢紊乱可引起生物体内多种致命疾病。因此，H2O2和葡萄糖的传感在疾病诊断和治疗中具有重要意义。荧光碳点 (CD) 是一类用于检测 H2O2 和葡萄糖的新型纳米探针。尽管如此，基于 CD 的传感器始终基于其荧光响应，这受到自发荧光干扰的影响。在此，通过一锅溶剂热法合成了高效的荧光 CDs，CDs 在双 (2,4,6-三氯苯基) 草酸盐和 H2O2 溶液中表现出明亮而持久的深红色 (DR) 化学发光 (CL)，具有 CL 量子(8.22 ± 0.30) × 10−3 的产量，这是有史以来报告的用于化学分析的纳米材料中的最高值之​​一。使用 CD 作为 CL 纳米探针，已经实现了对 H2O2 的灵敏传感，检测限为 11.7 μM，进一步用于葡萄糖检测，检测限为 12.6 μM。DR CL CDs 有望应用于血糖分析或体内生物传感器。