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Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-07-12 , DOI: 10.1111/cpr.12868 Hao Pan 1, 2 , Yuqing Lin 1 , Jianping Dou 3 , Zhen Fu 1 , Yanqing Yao 1 , Shanyu Ye 3 , Saixia Zhang 4 , Neng Wang 1 , Aijun Liu 4 , Xican Li 5 , Fengxue Zhang 1 , Dongfeng Chen 1, 3
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-07-12 , DOI: 10.1111/cpr.12868 Hao Pan 1, 2 , Yuqing Lin 1 , Jianping Dou 3 , Zhen Fu 1 , Yanqing Yao 1 , Shanyu Ye 3 , Saixia Zhang 4 , Neng Wang 1 , Aijun Liu 4 , Xican Li 5 , Fengxue Zhang 1 , Dongfeng Chen 1, 3
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Wedelolactone exhibits regulatory effects on some inflammatory diseases. However, the anti‐inflammatory mechanism of wedelolactone has not been entirely unravelled. Therefore, the present study focuses on investigating the mechanism of wedelolactone on NLRP3 inflammasome in macrophages and its influence on MSU‐induced inflammation.
中文翻译：
Wedelolactone 促进 NLRP3 的 Ser/Thr 磷酸化，依赖于 PKA 信号传导以阻断炎性体激活和细胞焦亡
Wedelolactone 对某些炎症性疾病具有调节作用。然而，韦德内酯的抗炎机制尚未完全阐明。因此，本研究的重点是研究韦德内酯对巨噬细胞中NLRP3炎性体的作用机制及其对MSU诱导的炎症的影响。
更新日期：2020-07-12
中文翻译：
Wedelolactone 促进 NLRP3 的 Ser/Thr 磷酸化，依赖于 PKA 信号传导以阻断炎性体激活和细胞焦亡
Wedelolactone 对某些炎症性疾病具有调节作用。然而，韦德内酯的抗炎机制尚未完全阐明。因此，本研究的重点是研究韦德内酯对巨噬细胞中NLRP3炎性体的作用机制及其对MSU诱导的炎症的影响。
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