Retrospective analysis of new psychoactive substances in blood samples of German drivers suspected of driving under the influence of drugs.,Drug Testing and Analysis

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Retrospective analysis of new psychoactive substances in blood samples of German drivers suspected of driving under the influence of drugs.
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-07-11 , DOI: 10.1002/dta.2897
Helena Fels ₁ , Josefine Herzog ₁ , Gisela Skopp ₁ , Anna Holzer ₂ , Liane D Paul ₂ , Matthias Graw ₂ , Frank Musshoff ₁

Affiliation

Driving under the influence of drugs (DUID) is a serious global problem and poses a public health risk. With new psychoactive substances (NPS) entering the illicit drug market several years ago, a significant number of highly potent and harmful drugs have become easily available and the use of these substances may impair a person’s ability to drive a vehicle safely. Since NPS are not usually covered in routine toxicological analyses used in DUID investigations, only little is known about their prevalence. To gather more information on the prevalence of NPS in cases of impaired driving, a retrospective study was conducted to determine the prevalence of these drugs in blood samples of DUID suspects in southern Germany. A total of 837 blood samples, which were collected in the German federal states Baden‐Württemberg and Bavaria in 2017 and 2018, were reanalyzed for designer stimulants and synthetic cannabinoids by liquid chromatography‐quadrupole‐time‐of‐flight mass spectrometry (LC‐QTOF‐MS). For the analysis of synthetic cannabinoids, a more sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) screening method was additionally used. A total of 14 cases (1.6%) tested positive for NPS. Designer stimulants were detected in two cases (0.2%) and synthetic cannabinoids were found in 12 cases (1.4%). The rather low prevalence rate of 1.6% estimated in this study suggests that driving under the influence of NPS does not play a large role in southern Germany. Nonetheless, in all cases in which the psychophysical impairment cannot be explained by routine toxicological findings, a screening for NPS should additionally be performed.

中文翻译：

对涉嫌吸毒驾驶的德国司机血样中新型精神活性物质的回顾性分析[J].

毒驾 (DUID) 是一个严重的全球性问题，对公共健康构成威胁。几年前，随着新的精神活性物质 (NPS) 进入非法药物市场，大量强效和有害的药物变得容易获得，使用这些物质可能会损害一个人安全驾驶车辆的能力。由于 DUID 调查中使用的常规毒理学分析通常不涉及 NPS，因此对其流行情况知之甚少。为了收集更多关于在驾驶障碍情况下 NPS 患病率的信息，进行了一项回顾性研究，以确定这些药物在德国南部 DUID 嫌疑人的血液样本中的患病率。2017 年和 2018 年在德国巴登符腾堡州和巴伐利亚州共采集了 837 份血液样本，通过液相色谱-四极杆飞行时间质谱 (LC-QTOF-MS) 重新分析了设计兴奋剂和合成大麻素。对于合成大麻素的分析，另外使用了更灵敏的液相色谱-串联质谱 (LC-MS/MS) 筛选方法。共有 14 例 (1.6%) 的 NPS 检测呈阳性。在 2 个案例 (0.2%) 中检测到设计兴奋剂，在 12 个案例 (1.4%) 中检测到合成大麻素。本研究中估计的 1.6% 的相当低的流行率表明，在德国南部，受 NPS 影响的驾驶并没有发挥很大的作用。尽管如此，在常规毒理学结果无法解释心理生理障碍的所有情况下，还应额外进行 NPS 筛查。

更新日期：2020-07-11

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