Implantable drug delivery systems that can realize a scheduled drug release according to the needs of patients would be highly beneficial for the treatment of chronic diseases and cancer. Here, micrometer‐sized hydrogel particles with both thermal and pH sensitivities are fabricated for the first time and embedded with magnetic nanoparticles in silk fibroin to generate a composite membrane. The permeability of the membrane is adjustable reversibly by temperature and pH. Promptly responded drug release within 1 min by applying an alternating magnetic field is demonstrated with the membrane. The on/off switching of an alternating magnetic field (16 mT, 111 kHz) induces heat generation by the magnetic nanoparticles resulting in a reversible change of the membrane permeability due to the shrinking/swelling of the microgels. A control over two orders of magnitude of the release rate (0.01–5.0 µg min⁻¹) of Rhodamine B (Rh.B) model drug is achieved by tuning the content of microgels and magnetic nanoparticles, as well as the thickness of the membrane. Additionally, an increase in the release rate of Rh.B in acidic condition with respect to the physiological pH value is demonstrated. This represents an additional functionality of the implantable membrane with relevant features for spatially selective cancer treatment.

中文翻译：

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通过施加交变磁场按需递送药物的热敏和pH敏感复合膜

可以根据患者需要实现预定的药物释放的可植入药物输送系统，对于治疗慢性疾病和癌症将非常有益。在这里，首次制造了具有热和pH敏感性的微米级水凝胶颗粒，并将其与磁性纳米颗粒包埋在丝素蛋白中以生成复合膜。膜的渗透性可通过温度和pH值可逆地调节。膜上显示了通过施加交变磁场在1分钟内迅速响应的药物释放。交变磁场（16 mT，111 kHz）的开/关切换会引起磁性纳米颗粒产生热量，由于微凝胶的收缩/膨胀，导致膜渗透性的可逆变化。罗丹明B（Rh.B）模型药物的^-1）是通过调整微凝胶和磁性纳米粒子的含量以及膜的厚度来实现的。另外，证明了相对于生理pH值，在酸性条件下Rh.B的释放速率增加。这代表具有相关特征的可植入膜的附加功能，用于空间选择性癌症治疗。