The majority of the known prognostic factors in dogs with lymphoma have been evaluated before treatment commences or at the time of diagnosis. Prognostic factors evaluated during the initial phase of treatment are less described but may provide important clinical information. In this retrospective study, 82 canine lymphoma patients were categorized according to the weight change between diagnosis and after 5 weeks of chemotherapy. Dogs that gained greater than 5% or lost greater than 5% of initial body weight were categorized as increased‐ or decreased‐weight groups, respectively. Those in which weight changed less than 5% were categorized as the maintained‐weight group. The median progression‐free survival (PFS) in the increased‐weight group, maintained‐weight group and decreased‐weight group was 226, 256 and 129 days, respectively. The decreased‐weight group had significantly shorter PFS than the increased and maintained groups (P = .023, P = .003, respectively). The median survival time (ST) in the increased‐weight group, maintained‐weight group and decreased‐weight group was 320, 339 and 222 days, respectively. There was no significant difference in ST among the three groups (P = .128). In Cox‐regression results, weight change group and initial body weight were significant risk factors associated to PFS (P = .007, P = .001, respectively) while only patient's initial body weight was a significant risk factor to ST (P = .013). In conclusion, evaluation of initial body weight and weight changes over time can provide valuable information regarding PFS and ST in dogs with multicentric lymphoma.

中文翻译：

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犬多中心淋巴瘤初始化疗期间体重变化与临床结果的相关性

在治疗开始前或诊断时，已经对患有淋巴瘤的犬的大多数已知预后因素进行了评估。在治疗的初始阶段评估的预后因素较少描述，但可能提供重要的临床信息。在这项回顾性研究中，根据诊断和化疗 5 周后的体重变化对 82 名犬淋巴瘤患者进行了分类。增加超过 5% 或减少超过初始体重 5% 的狗分别被归类为增重或减重组。体重变化小于5%的人被归类为维持体重组。增重组、维持体重组和减重组的中位无进展生存期 (PFS) 分别为 226、256 和 129 天。分别为 P = .023、P = .003）。增重组、维持体重组和减重组的中位生存时间（ST）分别为 320、339 和 222 天。三组之间的 ST 没有显着差异（P = .128）。在 Cox 回归结果中，体重变化组和初始体重是与 PFS 相关的显着危险因素（分别为P = .007 和P = .001），而只有患者的初始体重是 ST 的显着危险因素（P = .001）。 013)。总之，评估初始体重和体重随时间的变化可以提供关于患有多中心淋巴瘤的犬的 PFS 和 ST 的有价值的信息。