The cytotoxic synergy between Clostridioides difficile toxin B and proinflammatory cytokines: an unholy alliance favoring the onset of Clostridioides difficile infection and relapses.,MicrobiologyOpen

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The cytotoxic synergy between Clostridioides difficile toxin B and proinflammatory cytokines: an unholy alliance favoring the onset of Clostridioides difficile infection and relapses.
MicrobiologyOpen ( IF 3.9 ) Pub Date : 2020-07-12 , DOI: 10.1002/mbo3.1061
Gabrio Bassotti _{1,

2} , Andrea Marchegiani ₃ , Pierfrancesco Marconi ₄ , Katia Fettucciari ₄

Affiliation

Clostridioides difficile infection (CDI) represents an important health problem worldwide, with significant morbidity and mortality. This infection has also high recurrence rates, whose pathophysiological grounds are still poorly understood. Based on our experiments in vitro with Clostridioides difficile toxin B and existing experimental and clinical evidence, we propose that primary CDI and relapses might be favored by a mechanism that involves the enhancement of the toxicity of toxin B by proinflammatory cytokines, tumor necrosis factor alpha, and interferon gamma on the enteric glial cells and their network in an environment characterized by a strong dysmicrobism.

中文翻译：

艰难梭菌毒素B与促炎细胞因子之间的细胞毒性协同作用：一个邪恶的联盟，有利于艰难梭菌的感染和复发。

艰难梭菌感染（CDI）代表着世界范围内的重要健康问题，发病率和死亡率均很高。这种感染还具有较高的复发率，其病理生理学基础仍知之甚少。根据我们的艰难梭菌毒素B体外实验以及现有的实验和临床证据，我们提出原发性CDI和复发可能受到一种机制的支持，该机制涉及通过促炎性细胞因子，肿瘤坏死因子α增强毒素B的毒性，并在以强微生物为特征的环境中对肠神经胶质细胞及其网络产生干扰素γ。

更新日期：2020-07-12

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