Shining a Light on Bioorthogonal Photochemistry for Polymer Science.,Macromolecular Rapid Communications

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Shining a Light on Bioorthogonal Photochemistry for Polymer Science.
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2020-07-12 , DOI: 10.1002/marc.202000305
Nathan R B Boase _{1,

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Affiliation

Bioorthogonal chemistry is revolutionizing the fields of biological chemistry and nanomedicine, providing tools to actively probe and perturb native biochemical processes. Photochemistry provides the opportunity to actively and non‐invasively control bioorthogonal reactions, providing sophisticated optochemical tools. Despite the opportunities in bioorthogonal photochemistry, there remain many significant challenges to the clinical translation of current research. This review aims to provide an overview of these challenges and highlight recent examples from the literature that are providing revolutionary solutions to overcoming these barriers. It will highlight new photochemical systems that can be triggered by near infrared light in aqueous solutions and have been demonstrated to function in complex biological systems, including in living animals. It will cover diverse classes of photochemical reactions including photopolymerization, uncaging, conjugation, and photoswitching. The discussion will detail how new approaches are being integrated into polymers or highlight unexploited opportunities. This review intends to showcase how the unique synergy of bioorthogonal photochemistry and polymer science provides vast opportunities in the fields of biomaterials, nanomedicine, and theranostics. This will hopefully provide inspiration to material scientists to integrate bioorthogonal photochemistry into new adaptable materials and ensure translation to solve clinical challenges.

中文翻译：

在聚合物科学的生物正交光化学上开创先河。

生物正交化学正在彻底改变生物化学和纳米医学的领域，提供了主动探测和干扰自然生化过程的工具。光化学提供了主动和非侵入性控制生物正交反应的机会，提供了复杂的光化学工具。尽管有生物正交光化学方面的机会，但当前研究的临床翻译仍然面临许多重大挑战。这篇综述旨在概述这些挑战，并重点介绍文献中的最新例子，这些例子为克服这些障碍提供了革命性的解决方案。它将重点介绍可以由水溶液中的近红外光触发的新光化学系统，并已证明其在复杂的生物系统（包括活体动物）中起作用。它将涵盖各种类型的光化学反应，包括光聚合，解笼，共轭和光开关。讨论将详细介绍如何将新方法集成到聚合物中或突出未开发的机会。这篇综述旨在展示生物正交光化学和聚合物科学的独特协同作用如何在生物材料，纳米医学和治疗学领域提供巨大的机会。这有望为材料科学家提供启发，将生物正交光化学整合到新的适应性材料中，并确保翻译解决临床难题。讨论将详细介绍如何将新方法集成到聚合物中或突出未开发的机会。这篇综述旨在展示生物正交光化学和高分子科学的独特协同作用如何在生物材料，纳米医学和治疗学领域提供巨大的机会。这有望为材料科学家提供灵感，将生物正交光化学整合到新的适应性材料中，并确保翻译解决临床难题。讨论将详细介绍如何将新方法集成到聚合物中或突出未开发的机会。这篇综述旨在展示生物正交光化学和聚合物科学的独特协同作用如何在生物材料，纳米医学和治疗学领域提供巨大的机会。这有望为材料科学家提供启发，将生物正交光化学整合到新的适应性材料中，并确保翻译解决临床难题。

更新日期：2020-07-12

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