Hepatitis B and C viruses (HBV and HCV) are common causative pathogens of viral hepatitis. Progression of both infections is determined by virus‐ and host‐related factors. Cytokines are important host genetic factors that may have a predisposing role in HBV and HCV infections. This case‐control study evaluated the genetic association of IL4RA₊₁₉₀₂ (rs1801275), IL6₋₁₇₄ (rs1800795), IL6₋₅₉₇ (rs1800797), and IL12B₋₁₁₈₈ (rs3212227) variants with chronic HBV and HCV infections among Iraqi patients. A total of 220 viral hepatitis patients were enrolled in the study (113 HBV and 107 HCV), together with 141 healthy subjects. Sequence‐specific primer polymerase chain reaction assay was the genotyping method. Results revealed that under a dominant genetic model, IL6₋₁₇₄ variant was significantly associated with HBV infection, whereas no association with the HCV risk was reported. However, the risk for both infections was markedly associated with IL6₋₅₉₇ variant under recessive, dominant, and codominant genetic models. Estimation of IL6₋₁₇₄‐IL6₋₅₉₇ haplotypes depicted that G‐A haplotype was significantly associated with an increased risk to develop HBV infection, whereas a significantly decreased risk was associated with G‐G and C‐G haplotypes. For HCV, G‐G and C‐A haplotypes were significantly associated with risk of HCV infection. IL4RA₊₁₉₀₂ and IL12B₋₁₁₈₈ variants showed no association with HBV or HCV risk. Analysis of variance revealed no significant association between genotypes of the four determined single‐nucleotide polymorphisms and HBV or HCV viral load. In conclusion, the study supports the concept that IL6₋₅₉₇ variant is associated with susceptibility to HBV and HCV infections among Iraqis. The risk of HBV infection is further associated with IL6₋₁₇₄ variant.

中文翻译：

---

伊拉克患者 IL4RA、IL6 和 IL12B 基因的遗传变异以及乙型和丙型肝炎病毒感染的易感性。


乙型和丙型肝炎病毒（HBV和HCV）是病毒性肝炎的常见病原体。两种感染的进展均由病毒和宿主相关因素决定。细胞因子是重要的宿主遗传因素，可能在 HBV 和 HCV 感染中具有诱发作用。这项病例对照研究评估了伊拉克患者中IL4RA ₊₁₉₀₂ (rs1801275)、 IL6 _-174 (rs1800795)、 IL6 _-597 (rs1800797) 和IL12B _-1188 (rs3212227) 变异与慢性 HBV 和 HCV 感染的遗传关联。共有 220 名病毒性肝炎患者（113 名乙肝患者和 107 名丙肝患者）以及 141 名健康受试者参加了该研究。序列特异性引物聚合酶链反应测定是基因分型方法。结果显示，在显性遗传模型下， IL6 _-174变异与 HBV 感染显着相关，但与 HCV 风险没有相关性。然而，在隐性、显性和共显性遗传模型下，两种感染的风险均与IL6 _-597变异显着相关。 IL6 _-174 - IL6 _-597单倍型的估计表明，G-A 单倍型与发生 HBV 感染的风险增加显着相关，而 G-G 和 C-G 单倍型则风险显着降低。对于 HCV，G-G 和 C-A 单倍型与 HCV 感染风险显着相关。 IL4RA ₊₁₉₀₂和IL12B _-1188变异与 HBV 或 HCV 风险无关。 方差分析显示，四种确定的单核苷酸多态性的基因型与 HBV 或 HCV 病毒载量之间没有显着关联。总之，该研究支持这样的观点： IL6 _-597变异与伊拉克人对 HBV 和 HCV 感染的易感性相关。 HBV感染的风险进一步与IL6 _-174变异相关。