In patients with severe SARS‐CoV‐2 infection, the development of cytokine storm induces extensive lung damage, and monocytes play a role in this pathological process. Non‐classical (NC) and intermediate (INT) monocytes are known to be involved during viral and bacterial infections. In this study, 30 patients with different manifestations of acute SARS‐CoV‐2 infection were investigated with a flow cytometric study of NC, INT, and classical (CL) monocytes. Significantly reduced NC and INT monocytes and a downregulated HLA‐DR were found in acute patients with severe SARS‐CoV‐2 symptoms. Conversely in patients with moderate symptoms NC and INT monocytes and CD11b expression were increased. © 2020 International Society for Advancement of Cytometry

中文翻译：

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严重急性 SARS-CoV-2 感染中非经典和中间单核细胞亚群的减少。


在严重 SARS-CoV-2 感染的患者中，细胞因子风暴的发展会引起广泛的肺损伤，单核细胞在这一病理过程中发挥作用。已知非经典（NC）和中间（INT）单核细胞参与病毒和细菌感染。在这项研究中，对 30 名具有不同表现的急性 SARS-CoV-2 感染患者进行了 NC、INT 和经典 (CL) 单核细胞的流式细胞术研究。在患有严重 SARS-CoV-2 症状的急性患者中发现 NC 和 INT 单核细胞显着减少，HLA-DR 下调。相反，在中度症状的患者中，NC 和 INT 单核细胞以及 CD11b 表达增加。 © 2020 国际细胞计数促进会