There is currently no uniform definition of treatment response for posttraumatic stress disorder (PTSD) to guide researchers and clinicians in the area of posttraumatic mental health. The aim of this systematic review was to explore the operationalization of PTSD treatment response, by reviewing and synthesizing the key criteria used to define treatment response and treatment nonresponse in published trials. Randomized controlled trials (RCTs) assessing the effectiveness of first-line interventions for PTSD were identified for inclusion. Of those, 143 trials provided 226 definitions of treatment response, grouped under five main categories: treatment response (n = 181), remission (n = 23), recovery (n = 5), treatment nonresponse (n = 5), and worsening (n = 12). Overall, the results showed the PTSD field utilizes diverse and interchangeable operational definitions of treatment response and nonresponse, indicating a need for more precise conceptual definitions and operational criteria. A set of operational research definitions are presented in order to advance the PTSD treatment field.

中文翻译：

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定义对创伤后应激障碍治疗的反应和无反应：系统评价

目前对于创伤后应激障碍 (PTSD) 的治疗反应没有统一的定义，以指导创伤后心理健康领域的研究人员和临床医生。本系统评价的目的是通过回顾和综合已发表试验中用于定义治疗反应和治疗无反应的关键标准，探索 PTSD 治疗反应的操作化。确定纳入评估一线干预对 PTSD 的有效性的随机对照试验 (RCT)。其中，143 项试验提供了 226 种治疗反应的定义，分为五个主要类别：治疗反应（n =  181）、缓解（n  = 23）、恢复（n  = 5)、治疗无反应( n  = 5)和恶化( n  = 12)。总体而言，结果表明 PTSD 领域使用了治疗反应和无反应的多样化和可互换的操作定义，表明需要更精确的概念定义和操作标准。为了推进 PTSD 治疗领域，我们提出了一套操作性研究定义。