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Luminescence imaging-guided triple-collaboratively enhanced photodynamic therapy by bioresponsive lanthanide-based nanomedicine.
Nanomedicine: Nanotechnology, Biology and Medicine ( IF 4.2 ) Pub Date : 2020-07-12 , DOI: 10.1016/j.nano.2020.102265
Shuang Wang 1 , Zheng Wei 2 , Lin Li 1 , Xiaohui Ning 1 , Yuxin Liu 2
Affiliation  

Photodynamic therapy (PDT) provides a novel sight for non-invasive tumor ablation, which, however, is still limited by low converting efficiency and short life-time of produced singlet oxygen. In this work, a bioresponsive lanthanide-based nanomedicine, FeOOH-coated and toluidine blue (TB)-loaded NaLuF4:Yb,Er,Tm@NaLuF4, is constructed for tumor microenvironment-activated photodynamic therapy with triple-collaborative enhancing strategy. In response to intratumoral reducibility and acidity, coated FeOOH decomposes, eliminating reduced glutathione (GSH) and up-regulating intratumoral oxidative stress to enhance PDT. Besides, Fe2+ is also released from this redox process, which can improve intratumoral dissolved O2 for PDT by catalytic decomposition of H2O2. Lastly, quenched upconversion luminescence of lanthanide-doped nanoparticles also recovers, which allows more efficient energy transfer to TB and hence improves PDT efficiency. By the above triple-collaborative strategy, highly efficient photodynamic tumor ablation is performed in vivo. This work proposes a rigorous method to elevate photodynamic therapeutic efficiency.



中文翻译:

发光成像引导的基于生物反应性镧系元素的纳米药物三协同增强的光动力疗法。

光动力疗法(PDT)为非侵入性肿瘤消融提供了一种新颖的方法,但是,它仍然受到转化效率低和产生的单线态氧寿命短的限制。在这项工作中,构建了一种基于生物响应性镧系元素的纳米药物,FeOOH涂层和甲苯胺蓝(TB)负载的NaLuF 4:Yb,Er,Tm @ NaLuF 4,用于具有三重协同增强策略的肿瘤微环境激活的光动力疗法。响应于肿瘤内可还原性和酸度,包被的FeOOH分解,消除了减少的谷胱甘肽(GSH)并上调了肿瘤内氧化应激以增强PDT。此外,Fe 2+也从该氧化还原过程中释放出来,可以改善肿瘤内溶解的O 2通过H 2 O 2催化分解制备PDT 。最后,掺杂镧系元素的纳米粒子的淬灭上转换发光也得以恢复,这使能量更有效地转移至TB,从而提高了PDT效率。通过以上三重协作策略,在体内进行高效的光动力肿瘤消融。这项工作提出了一种严格的方法来提高光动力治疗效率。

更新日期:2020-07-12
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