Photodynamic therapy (PDT) provides a novel sight for non-invasive tumor ablation, which, however, is still limited by low converting efficiency and short life-time of produced singlet oxygen. In this work, a bioresponsive lanthanide-based nanomedicine, FeOOH-coated and toluidine blue (TB)-loaded NaLuF₄:Yb,Er,Tm@NaLuF₄, is constructed for tumor microenvironment-activated photodynamic therapy with triple-collaborative enhancing strategy. In response to intratumoral reducibility and acidity, coated FeOOH decomposes, eliminating reduced glutathione (GSH) and up-regulating intratumoral oxidative stress to enhance PDT. Besides, Fe²⁺ is also released from this redox process, which can improve intratumoral dissolved O₂ for PDT by catalytic decomposition of H₂O₂. Lastly, quenched upconversion luminescence of lanthanide-doped nanoparticles also recovers, which allows more efficient energy transfer to TB and hence improves PDT efficiency. By the above triple-collaborative strategy, highly efficient photodynamic tumor ablation is performed in vivo. This work proposes a rigorous method to elevate photodynamic therapeutic efficiency.

光动力疗法（PDT）为非侵入性肿瘤消融提供了一种新颖的方法，但是，它仍然受到转化效率低和产生的单线态氧寿命短的限制。在这项工作中，构建了一种基于生物响应性镧系元素的纳米药物，FeOOH涂层和甲苯胺蓝（TB）负载的NaLuF ₄：Yb，Er，Tm @ NaLuF ₄，用于具有三重协同增强策略的肿瘤微环境激活的光动力疗法。响应于肿瘤内可还原性和酸度，包被的FeOOH分解，消除了减少的谷胱甘肽（GSH）并上调了肿瘤内氧化应激以增强PDT。此外，Fe ²⁺也从该氧化还原过程中释放出来，可以改善肿瘤内溶解的O ₂通过H ₂ O ₂催化分解制备PDT 。最后，掺杂镧系元素的纳米粒子的淬灭上转换发光也得以恢复，这使能量更有效地转移至TB，从而提高了PDT效率。通过以上三重协作策略，在体内进行了高效的光动力肿瘤消融。这项工作提出了一种严格的方法来提高光动力治疗效率。