Unilateral chronic pulsatile headache as the single manifestation of anti-MOG antibody-associated unilateral cerebral cortical encephalitis,Journal of Neuroimmunology

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Unilateral chronic pulsatile headache as the single manifestation of anti-MOG antibody-associated unilateral cerebral cortical encephalitis
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.jneuroim.2020.577322
Juichi Fujimori ₁ , Ryo Ogawa ₂ , Takaki Murata ₃ , Kazutaka Jin ₄ , Yukako Yazawa ₅ , Ichiro Nakashima ₁

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Unilateral cerebral cortical encephalitis (UCCE) with myelin oligodendrocyte glycoprotein (MOG)-antibody comprises a new spectrum of disease entities generally presenting seizures. Here, we report a case of a young adult with anti-MOG antibody-associated UCCE who only presented persistent left pulsatile headache. Neurological examination revealed no deficits. Brain MRI showed a fluid-attenuated inversion recovery hyperintense lesion along the swollen left cerebral cortex. The patient was positive for anti-MOG antibodies. We diagnosed him with anti-MOG antibody-associated UCCE. Immediately after the administration of high-dose IV methylprednisolone, the headache diminished. Anti-MOG antibody-associated UCCE is a new differential diagnosis in patients with unilateral chronic pulsatile headache.

中文翻译：

以单侧慢性搏动性头痛为抗MOG抗体相关性单侧大脑皮质脑炎的单一表现

具有髓鞘少突胶质细胞糖蛋白 (MOG) 抗体的单侧大脑皮质脑炎 (UCCE) 包括一系列新的疾病实体，通常表现为癫痫发作。在此，我们报告一例患有抗 MOG 抗体相关 UCCE 的年轻成人病例，仅表现为持续性左侧搏动性头痛。神经系统检查未发现任何缺陷。脑部 MRI 显示，肿胀的左侧大脑皮层存在液体衰减反转恢复性高信号病变。该患者的抗 MOG 抗体呈阳性。我们诊断他患有抗 MOG 抗体相关的 UCCE。给予高剂量静脉注射甲泼尼龙后，头痛立即减轻。抗 MOG 抗体相关 UCCE 是单侧慢性搏动性头痛患者的一种新鉴别诊断。

更新日期：2020-09-01

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