Though ingestion and inhalation of dust have been suggested as important exposure routes contributing chlorinated paraffins (CPs) build-up in humans, the bioaccessibility of dust-borne CPs in the organ environment has not been well-studied, which may hinder an accurate estimation of exposure risks. In this study, the ingestion and inhalation bioaccessibility of dust-borne short- and median-chain CPs (SCCPs and MCCPs) was assessed using (colon-extended) physiologically based extraction test with the addition of Tenax. The ingestion bioaccessibility of SCCPs 51.5 %Cl, SCCPs 63 %Cl, MCCPs 42 %Cl, and MCCPs 57 %Cl was in ranges of 21.1–44.0 %, 11.7–45.8 %, 21.9–36.6 %, and 7.9–32.9 %, respectively. Multiple linear regression analysis demonstrated statistically significant associations of ingestion bioaccessibility with carbon chain length and chlorine substitution. The ingestion bioaccessibility of CPs also increased with co-existence of carbohydrate/protein. The inhalation bioaccessibility of SCCPs (16.7–38.7 % in artificial lysosomal fluid and 15.5–34.1 % in modified Gamble solution) was significantly higher than MCCPs (<5 %), and varied with dust particle size/total organic carbon content. Our study indicates that modest bioaccessible fractions of CPs in dust should be taken into account to refine the estimation of human exposure, and their bioaccessibility may be affected by CP molecular size, nutritional content and dust property.

尽管已建议摄入和吸入粉尘是导致人体中积累氯化石蜡（CP）的重要接触途径，但尚未充分研究粉尘型CP在器官环境中的生物可及性，这可能会妨碍对粉尘CP的准确估计。暴露风险。在这项研究中，粉尘传播的短链和中链CP（SCCP和MCCP）的摄入和吸入生物可及性（采用扩展的）基于生理学的提取试验（加Tenax）进行了评估。SCCPs 51.5％Cl，SCCPs 63％Cl，MCCPs 42％Cl和MCCPs 57％Cl的摄入生物可及性分别在21.1–44.0％，11.7–45.8％，21.9–36.6％和7.9–32.9％范围内。多元线性回归分析表明，摄入生物可及性与碳链长度和氯取代在统计学上具有显着相关性。碳水化合物的摄取生物可及性也随着碳水化合物/蛋白质的共存而增加。SCCPs的吸入生物可及性（在人工溶酶体液中为16.7％至38.7％，在改良的Gamble溶液中为15.5至34.1％）显着高于MCCPs（<5％），并且随粉尘粒径/总有机碳含量而变化。我们的研究表明，应考虑灰尘中CP的适度生物可及部分，以完善对人体暴露的估计，其生物可及性可能受CP分子大小，营养成分和粉尘特性的影响。碳水化合物的摄取生物可及性也随着碳水化合物/蛋白质的共存而增加。SCCPs的吸入生物可及性（在人工溶酶体液中为16.7％至38.7％，在改良的Gamble溶液中为15.5至34.1％）显着高于MCCPs（<5％），并且随粉尘粒径/总有机碳含量而变化。我们的研究表明，应考虑灰尘中CP的适度生物可及部分，以完善对人体暴露的估计，其生物可及性可能受CP分子大小，营养成分和粉尘特性的影响。碳水化合物的摄取生物可及性也随着碳水化合物/蛋白质的共存而增加。SCCPs的吸入生物可及性（在人工溶酶体液中为16.7％至38.7％，在改良的Gamble溶液中为15.5至34.1％）显着高于MCCPs（<5％），并且随粉尘粒径/总有机碳含量而变化。我们的研究表明，应考虑灰尘中CP的适度生物可及部分，以完善对人体暴露的估计，其生物可及性可能受CP分子大小，营养成分和粉尘特性的影响。