The present study aimed to evaluate the effects of lutein on blue LED light-induced retinal injury. Animals were randomly assigned to six groups. Distilled water (normal control and water-light group), corn oil (solvent-light group), or 25, 50, or 100 mg/kg lutein in corn oil (three lutein treatment groups) were administered intragastrically for 30 days. The experimental rats (all groups other than the normal control group) were exposed to 1500 lx for 1.5 h after pretreatment. Lutein pretreatment significantly attenuated the decrease in the electroretinogram (ERG) a-wave and b-wave amplitudes and the thinning of the photoreceptor cell layer caused by apoptosis; inhibited light-induced oxidative stress in the retinal tissues; and suppressed the increase in inflammatory cytokine levels. Moreover, the expression of BCO2 was significantly upregulated with lutein supplementation in retinas exposed to light. Our results suggested that lutein protected the retina for light induced retinal damage by inhibiting oxidative stress and inflammation.

本研究旨在评估叶黄素对蓝光LED引起的视网膜损伤的影响。将动物随机分为六组。胃内给予蒸馏水（正常对照组和轻水组），玉米油（溶剂轻组）或玉米油中的25、50或100 mg / kg叶黄素（三个叶黄素治疗组），胃内给药30天。预处理后，将实验大鼠（除正常对照组外的所有其他组）暴露于1500 lx下1.5 h。叶黄素预处理显着减弱了由凋亡引起的视网膜电图（ERG）a波和b波幅值的减小以及感光细胞层的变薄。抑制视网膜组织中光诱导的氧化应激；并抑制了炎症细胞因子水平的升高。此外，叶黄素补充剂在暴露于视网膜的视网膜中BCO2的表达显着上调。我们的结果表明，叶黄素可通过抑制氧化应激和炎症来保护视网膜免受光诱导的视网膜损伤。