Dysregulation of glucose homeostasis result in hyperglycemia and pigmented rice, unique combination of high quality starch and phenolics has the potential in regulating it. In this study, pigmented rice was characterized in terms of nutraceutical starch (NS) and phenolic content. Further the effect of rice phenolics on carbolytic enzyme inhibition, glucose uptake, hepatic glucose homeostasis and anti-glycation ability was analyzed in vitro. The most relevant effect on enzyme inhibition (α-amylase: IC₅₀-42.34 µg/mL; α-glucosidase: IC₅₀:63.89 µg/mL), basal uptake of glucose (>39.5%) and anti-glycation ability (92%) was found in red rice (RR), than black rice (BR). The role of RR phenolics in regulating glucose homeostasis was deciphered using hepatic cell line system, which found up-regulation of glucose transporter 2 (GLUT2) and glycogen synthase 2 (GYS2); while expression of gluconeogenic genes were found down regulated. To our knowledge this study is the first report validating the role of starch-phenolic quality towards anti-hyperglycemic effect of RR.

葡萄糖稳态的失调导致高血糖症和米色米，优质淀粉和酚类的独特结合具有调节它的潜力。在这项研究中，有色大米通过营养淀粉（NS）和酚含量进行了表征。进一步进行了分析上carbolytic酶抑制，葡萄糖摄取，肝葡萄糖稳态和抗糖化能力大米酚类的效果的体外。与酶抑制作用最相关的作用（α-淀粉酶：IC ₅₀ -42.34 µg / mL；α-葡萄糖苷酶：IC ₅₀：63.89 µg / mL），红米（RR）比黑米（BR）的基本葡萄糖吸收（> 39.5％）和抗糖化能力（92％）。使用肝细胞系来解释RR酚类药物在调节葡萄糖稳态中的作用，该系统发现了葡萄糖转运蛋白2（GLUT2）和糖原合酶2（GYS2）的上调。同时发现糖异生基因的表达下调。据我们所知，该研究是第一个证实淀粉-酚类物质对RR抗降血糖作用的作用的报告。