This review focuses on the Cbl-b muscle atrophy-associated ubiquitin ligase and its inhibitors. Herein, the role of E3 ubiquitin ligase-associated muscle atrophy genes (atrogenes), including MAFbx-1/agrogin-1 and MuRF-1, as well as another ubiquitin ligase, Cbl-b and its inhibitors, is discussed. Cbl-b plays an important role in unloading muscle atrophy caused by spaceflight and in bedridden patients: Cbl-b ubiquitinated and induced the degradation of IRS-1, a key intermediate in the IGF-1 signaling. Furthermore, a pentapetpide (DGpYMP), inhibited Cbl-b-mediated IRS-1 ubiquitination. This peptide-based Cbl-b inhibitor Cblin and its homologous peptides in foods presumably affect muscle atrophy under such conditions.

这篇综述集中在与Cbl-b肌肉萎缩相关的泛素连接酶及其抑制剂。在此，讨论了E3泛素连接酶相关的肌肉萎缩基因（atrogenes），包括MAFbx-1 / agrogin-1和MuRF-1，以及另一种泛素连接酶Cbl-b及其抑制剂的作用。Cbl-b在减轻由航天和卧床不起的患者引起的肌肉萎缩中起着重要作用：Cbl-b泛素化并诱导了IRS-1（IGF-1信号传导的关键中间产物）的降解。此外，五肽（DGpYMP）抑制Cbl-b介导的IRS-1泛素化。在这种情况下，这种基于肽的Cbl-b抑制剂Cblin及其食物中的同源肽可能会影响肌肉萎缩。