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Dietary citrus peel essential oil ameliorates hypercholesterolemia and hepatic steatosis by modulating lipid and cholesterol homeostasis.
Food & Function ( IF 5.1 ) Pub Date : 2020-07-10 , DOI: 10.1039/d0fo00810a Konglong Feng 1 , Xiaoai Zhu , Guo Liu , Qixin Kan , Tong Chen , Yunjiao Chen , Yong Cao
Food & Function ( IF 5.1 ) Pub Date : 2020-07-10 , DOI: 10.1039/d0fo00810a Konglong Feng 1 , Xiaoai Zhu , Guo Liu , Qixin Kan , Tong Chen , Yunjiao Chen , Yong Cao
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Citrus peel essential oil (CPEO) contains abundant volatile compounds and exhibits fragrance properties and beneficial pharmacological effects on humans. Herein, we aimed to investigate the effects of CPEO on the prevention of hypercholesterolemia and hepatic steatosis in high-fat diet-fed rats and identify its possible regulatory mechanisms in lipid metabolism by combining lipidomics with gene expression analysis. CPEO at effective supplementation levels of 0.5% and 0.75% significantly ameliorated hypercholesterolemia and hepatic steatosis, including decreased serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), hepatic TC and triglyceride (TG) levels, and hepatic lipid droplet accumulation. Lipidomics analysis revealed that the total levels of fatty acid (FFA), TG and cholesteryl ester (CE) classes in the liver tissue were remarkably decreased after 0.75% CPEO supplementation some of which (3 TGs and 4 CEs) might emerge as potential lipid biomarkers in response to the effects of CPEO. Furthermore, these lipidomics findings were associated with downregulation of lipogenesis-related genes SREBP-1c, ACC and FAS and upregulation of bile acid biosynthesis-related genes LXRα, CYP7A1 and CYP27A1 in the liver. This study indicated that CPEO could effectively prevent hypercholesterolemia and hepatic steatosis, possibly because of its mediation of lipid and cholesterol homeostasis by altering liver lipid metabolites and regulating lipid metabolism-related genes.
中文翻译：
日粮柑橘皮精油可通过调节脂质和胆固醇的体内稳态来改善高胆固醇血症和肝脂肪变性。
柑桔皮香精油（CPEO）含有丰富的挥发性化合物，并具有芳香特性和对人体有益的药理作用。在本文中，我们旨在研究CPEO对高脂饮食喂养的大鼠高胆固醇血症和肝脂肪变性的预防作用，并通过将脂质组学与基因表达分析相结合来确定其在脂质代谢中的可能调控机制。有效补充水平为0.5％和0.75％的CPEO可显着改善高胆固醇血症和肝脂肪变性，包括降低血清总胆固醇（TC），低密度脂蛋白胆固醇（LDL-c），肝TC和甘油三酸酯（TG）的水平以及肝脂质液滴堆积。脂质组学分析表明，脂肪酸（FFA）的总含量 补充0.75％CPEO后，肝脏组织中的TG和胆固醇酯（CE）类别显着降低，其中一些（3 TG和4 CEs）可能会响应CPEO的作用而成为潜在的脂质生物标志物。此外，这些脂质组学研究结果与脂肪生成相关基因的下调有关肝脏中SREBP-1c，ACC和FAS以及胆汁酸生物合成相关基因LXRα，CYP7A1和CYP27A1的上调。这项研究表明，CPEO可以有效预防高胆固醇血症和肝脂肪变性，可能是因为它通过改变肝脏脂质代谢产物和调节脂质代谢相关基因来介导脂质和胆固醇稳态。
更新日期：2020-08-19
中文翻译：
日粮柑橘皮精油可通过调节脂质和胆固醇的体内稳态来改善高胆固醇血症和肝脂肪变性。
柑桔皮香精油（CPEO）含有丰富的挥发性化合物，并具有芳香特性和对人体有益的药理作用。在本文中，我们旨在研究CPEO对高脂饮食喂养的大鼠高胆固醇血症和肝脂肪变性的预防作用，并通过将脂质组学与基因表达分析相结合来确定其在脂质代谢中的可能调控机制。有效补充水平为0.5％和0.75％的CPEO可显着改善高胆固醇血症和肝脂肪变性，包括降低血清总胆固醇（TC），低密度脂蛋白胆固醇（LDL-c），肝TC和甘油三酸酯（TG）的水平以及肝脂质液滴堆积。脂质组学分析表明，脂肪酸（FFA）的总含量 补充0.75％CPEO后，肝脏组织中的TG和胆固醇酯（CE）类别显着降低，其中一些（3 TG和4 CEs）可能会响应CPEO的作用而成为潜在的脂质生物标志物。此外，这些脂质组学研究结果与脂肪生成相关基因的下调有关肝脏中SREBP-1c，ACC和FAS以及胆汁酸生物合成相关基因LXRα，CYP7A1和CYP27A1的上调。这项研究表明，CPEO可以有效预防高胆固醇血症和肝脂肪变性，可能是因为它通过改变肝脏脂质代谢产物和调节脂质代谢相关基因来介导脂质和胆固醇稳态。
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