ABSTRACT

The capability to hinder microbial growth on the implant surfaces is of great interest in medical applications. This paper presents our study on the synthesis of zeolite/silver-graphene oxide (Zeo/Ag-GO) nanocomposite to enhance antibacterial activities of bone implants. Zeo/Ag-GO was synthesized using via semi-powder metallurgy and then characterized in terms of microstructure, antibacterial activities, and biocompatibility. Our microstructure results demonstrated that the Ag particles were anchored and uniformly distributed in the composite structure; assessment of antibacterial activity against the Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus) revealed that Zeo/Ag-GO was better than Zeo/Ag, but Zeo has no antimicrobial activity observed; and biocompatibility assays showed that both Zeo/Ag and Zeo/Ag-GO had no negative effect on the proliferation of MG-63, while Zeo/Ag-GO promoted better cell viability. Taken together, Zeo/Ag-GO has great antimicrobial performance with suitable cytocompatibility, thus potentially being used to reduce implant-associated infections.

摘要

阻止微生物在植入物表面生长的能力在医疗应用中引起了极大的兴趣。本文介绍了我们对沸石/银-氧化石墨烯（Zeo/Ag-GO）纳米复合材料的合成以增强骨植入物的抗菌活性的研究。Zeo/Ag-GO 是通过半粉末冶金合成的，然后在微观结构、抗菌活性和生物相容性方面进行表征。我们的微观结构结果表明，Ag 颗粒被锚定并均匀分布在复合结构中；对革兰氏阴性大肠杆菌（E.coli）和革兰氏阳性金黄色葡萄球菌（S.aureus）的抗菌活性评估表明，Zeo/Ag-GO 优于 Zeo/Ag，但 Zeo 没有观察到抗菌活性；和生物相容性试验表明，Zeo/Ag 和 Zeo/Ag-GO 对 MG-63 的增殖没有负面影响，而 Zeo/Ag-GO 促进了更好的细胞活力。总之，Zeo/Ag-GO 具有良好的抗菌性能和合适的细胞相容性，因此有可能用于减少植入物相关感染。