ABSTRACT

Arsenic is a toxic substance that causes tissue damage. It is well-known that exposure to this substance induces oxidative stress and causes liver injury. The present study has been conducted to evaluate the protective role of raw or irradiated basil against arsenic-induced liver damage. Basil leaves were irradiated at a dose of 10 kGy by cobalt-60 gamma rays. Forty-eight female albino rats were divided into six groups where the ‘Control’ group received distilled water, ‘Basil’ group received water extract of raw basil, ‘Irr. Basil’ group received water extract of irradiated basil, ‘As’ group received arsenic, ‘As+Basil’ and ‘As+Irr. basil’ groups received a water extract of either raw or irradiated basil along with arsenic. Results showed that exposure basil leaves to gamma-irradiation increased their antioxidants. Exposure of rats to arsenic resulted in increased hepatic enzymes as well as increased hepatic oxidative stress with a decline in hepatic antioxidants. The administration of raw or irradiated basil to arsenic-exposed rats has significantly reduced serum enzyme activity accompanied by an improvement in the liver’s antioxidant/oxidant status. In conclusion, our findings showed that radiation is effective in improving basil antioxidants. Furthermore, raw or irradiated basil can protect against hepatic injury caused by arsenic.

摘要

砷是一种有毒物质，会引起组织损伤。众所周知，接触该物质会引起氧化应激并引起肝损伤。本研究已经进行以评估生的或辐射的罗勒对砷诱导的肝损伤的保护作用。罗勒叶用钴60伽玛射线辐照，剂量为10 kGy。将48只白化病雌性大鼠分为六组，“对照组”接受蒸馏水，“罗勒”组接受生罗勒的水提取物“ Irr”。罗勒（Basil）组接受辐照罗勒的水提取物，'阿斯（As）组接受砷，'As + Basil'和'As + Irr。罗勒的研究小组收到了生的或辐射的罗勒以及砷的水提取物。结果表明，罗勒叶在伽玛射线照射下会增加其抗氧化剂。大鼠接触砷会导致肝酶增加以及肝氧化应激增加，肝抗氧化剂减少。向暴露于砷的大鼠施用生的或辐射的罗勒，可显着降低血清酶的活性，并改善肝脏的抗氧化剂/氧化剂状态。总之，我们的发现表明，辐射能有效改善罗勒抗氧化剂。此外，生的或辐照的罗勒可以保护免受砷引起的肝损伤。我们的研究结果表明，辐射能有效改善罗勒抗氧化剂。此外，生的或辐照的罗勒可以保护免受砷引起的肝损伤。我们的研究结果表明，辐射能有效改善罗勒抗氧化剂。此外，生的或辐照的罗勒可以保护免受砷引起的肝损伤。