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The pathogenesis of cutaneous lupus erythematosus: The aberrant distribution and function of different cell types in skin lesions.
Scandinavian Journal of Immunology ( IF 4.1 ) Pub Date : 2020-07-12 , DOI: 10.1111/sji.12933
Xinyu Zhou 1, 2 , Jinli Yan 1, 2 , Qianjin Lu 3 , Honghao Zhou 1, 2 , Lan Fan 1, 2
Affiliation  

Cutaneous lupus erythematosus (CLE) is an autoimmune disease with a broad range of cutaneous manifestations. In skin lesions of CLE, keratinocytes primarily undergo apoptosis. Interferon‐κ(IFN‐κ) is belonged to type I interferons (type I IFNs) and is selectively produced by keratinocytes. Recently, keratinocytes selectively produced IFN‐κ is identified to be a key to trigger type I interferon responses in CLE. Other immune cells such as plasmacytoid dendritic cells (pDCs) are identified to be relevant origin of type I interferons (type I IFNs) which are central to the development of CLE lesions and responsible for mediating Th1 cell activity. Other types of cells such as neutrophils, B cells and Th17 cells also are involved in the development of this disease. The close interaction of those cells composes a comprehensive and complicated network in CLE. In this review, we discussed the aberrant distribution and function of different cells types involved in this disease and will offer a new direction for research and therapy in the near future.

中文翻译:

皮肤红斑狼疮的发病机制:皮肤病变中不同细胞类型的异常分布和功能。

皮肤红斑狼疮(CLE)是一种自身免疫性疾病,具有广泛的皮肤表现。在CLE的皮肤病变中,角质形成细胞主要经历凋亡。干扰素κ(IFN-κ)属于I型干扰素(I型IFN),由角质形成细胞选择性产生。最近,已确定选择性产生的IFN-κ角质形成细胞是引发CLE中I型干扰素反应的关键。其他免疫细胞(如浆细胞样树突状细胞(pDC))被确定为I型干扰素(I型IFN)的相关来源,这些干扰素对CLE病变的发展至关重要,并负责介导Th1细胞活性。其他类型的细胞,例如中性粒细胞,B细胞和Th17细胞也参与了该疾病的发展。这些单元的紧密交互构成了CLE中一个全面而复杂的网络。在这篇综述中,我们讨论了与该疾病有关的不同细胞类型的异常分布和功能,并将在不久的将来为研究和治疗提供新的方向。
更新日期:2020-07-12
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