Synthesis of supercritical carbon dioxide‐philic phospholipids and determination of their solubility,Polymer Engineering and Science

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Synthesis of supercritical carbon dioxide‐philic phospholipids and determination of their solubility
Polymer Engineering and Science ( IF 3.2 ) Pub Date : 2020-07-11 , DOI: 10.1002/pen.25476
Junying Song ₁ , Zhen Jiao _{1,

2} , Jiangrui Cheng ₁ , Ningjie Ruan ₁ , Lixia Yang ₁

Affiliation

The supercritical technology is a promising green process in the fields of medicine, cosmetics, food, and feed industries. However, the poor solubility of phospholipid in supercritical carbon dioxide (ScCO₂) limits its application in some processes. In order to enhance the solubility, a modified phospholipid with ScCO₂‐philic group (eg, polyvinyl acetate), is designed and successfully synthesized. The solubility of the ScCO₂‐philic phospholipids in ScCO₂ with ethanol as cosolvent (0.5, 1.0, 2.0 mol%) is determined at the temperatures of 313.15, 318.15, 323.15, 328.15 K, and the pressure range of 9 to 15 MPa. The determination results indicate that the solubility of the modified phospholipid in ScCO₂ is much higher than that of the soybean phospholipids. Furthermore, five semiempirical equations, namely, Chrastil‐G, MST‐S, Sodeifian‐Sajadian, Pérez, and Reddy, are used to correlate and predict the experimental results. The average absolute relative deviations of the correlation equations are 6.91%, 7.08%, 6.06%, 2.62%, and 6.15%, respectively, indicating that the solubility data can be well predicted.

中文翻译：

超临界二氧化碳亲油磷脂的合成及其溶解度的测定

在医药，化妆品，食品和饲料工业领域中，超临界技术是一种有前途的绿色工艺。但是，磷脂在超临界二氧化碳（ScCO ₂）中的溶解性差，限制了其在某些工艺中的应用。为了提高溶解度，设计并成功合成了具有ScCO _2-亲电基团的改性磷脂（例如聚乙酸乙烯酯）。在温度为313.15、318.15、323.15、328.15 K，压力范围为9到15 MPa的条件下，以乙醇为助溶剂（0.5、1.0、2.0 mol％）测定ScCO _2-亲脂性磷脂在ScCO _2中的溶解度。测定结果表明，改性磷脂在ScCO ₂中的溶解度远高于大豆磷脂。此外，使用五个半经验方程，即Chrastil-G，MST-S，Sodeifian-Sajadian，Pérez和Reddy，来关联和预测实验结果。相关方程的平均绝对相对偏差分别为6.91％，7.08％，6.06％，2.62％和6.15％，表明可以很好地预测溶解度数据。

更新日期：2020-09-16

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