当前位置: X-MOL 学术Angew. Chem. Int. Ed. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Merging Electrosynthesis and Bifunctional Squaramide Catalysis in the Asymmetric Detrifluoroacetylative Alkylation Reactions.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-07-11 , DOI: 10.1002/anie.202006903
Xihao Chang 1 , Jiayin Zhang 1 , Qinglin Zhang 1 , Chang Guo 1
Affiliation  

An enantioselective bifunctional squaramide‐catalyzed detrifluoroacetylative alkylation reaction has been developed under electrochemical conditions. The unified strategy based on this key tandem methodology has been divergently explored for the asymmetric synthesis of fluorine‐containing target molecules with good stereocontrol (up to 95 % ee). Furthermore, this asymmetric catalytic reaction combines the benefits of electrosynthesis and organocatalysis for the preparation of biologically relevant products containing C‐F tertiary stereogenic centers.

中文翻译:

在不对称的三氟乙酰化烷基化反应中合并电合成和双功能方酰胺催化。

在电化学条件下,开发了对映选择性的双功能方酰胺催化的三氟乙酰化烷基化反应。对于这种具有良好立体控制(高达95%ee)的含氟靶分子的不对称合成,已经广泛探索了基于这种关键串联方法的统一策略。此外,这种不对称催化反应结合了电合成和有机催化的优势,可用于制备含有C-F三级立体异构中心的生物学相关产品。
更新日期:2020-07-11
down
wechat
bug