Implant infections caused by bacteria and oxidative stress induced by reactive oxygen species (ROS) would seriously hinder the osseointegration at the interface of bone and titanium (Ti) implant, leading to a failure. Therefore, it is highly desirable to develop an implant surface modification with antibacterial and antioxidant functions. Silver (Ag), which exhibit a broad spectrum of antibacterial properties, was used in this work. Tannic acid (TA) was selected as the reducing agent to realize the generation of Ag nanoparticles, and as an antioxidant to achieve the antioxidative activity of Ti implants. So, a layer of anatase titanium dioxide (TiO₂) nanotubes with a diameter of 138.72 ± 14.02 nm was formed on the surface of Ti substrate by anodization and annealing, followed by loading Ag nanoparticles, growing bioactive hydroxyapatite (HA) crystals, and finally forming Ag-HA/TA composite coatings. Morphology and phase composition investigations detected the presence of Ag nanoparticles and HA crystals in the coatings. The results reveal the uniformly distributed Ag particles with a diameter of about 20– 80 nm and needle-like HA crystals with a diameter of about 18– 20 nm. Results of total antioxidant capacity tests indicate that the slow release of TA from the composite coatings leads to a persistent antioxidative activity. The antibacterial and cell compatibility tests in vitro reveal that the Ag-HA/TA coating has high antibacterial activity against both Escherichia coli and Staphylococcus aureus and good cytocompatibility effect with MC3T3-E1 cell lines. This study presents a simple and effective method for the incorporation of antibacterial agents and antioxidant into HA coatings to modify metallic implant surfaces.

由细菌引起的植入物感染和活性氧（ROS）引起的氧化应激会严重阻碍骨骼与钛（Ti）植入物界面的骨整合，从而导致失败。因此，非常需要开发一种具有抗菌和抗氧化功能的植入物表面改性剂。具有广泛抗菌特性的银（Ag）用于这项工作。选择单宁酸（TA）作为还原剂以实现Ag纳米粒子的产生，并选择抗氧化剂以实现Ti植入物的抗氧化活性。因此，一层锐钛矿型二氧化钛（TiO ₂通过阳极氧化和退火在Ti基体表面形成直径为138.72±14.02 nm的纳米管，然后加载Ag纳米颗粒，生长生物活性羟基磷灰石（HA）晶体，最后形成Ag-HA / TA复合涂层。形态和相组成研究检测到涂层中存在银纳米颗粒和HA晶体。结果显示出直径约20–80 nm的均匀分布的银粒子和直径约18–20 nm的针状HA晶体。总抗氧化剂容量测试的结果表明，TA从复合涂层中的缓慢释放导致持久的抗氧化活性。体外抗菌和细胞相容性测试表明，Ag-HA / TA涂层对两种细菌都有很高的抗菌活性。大肠杆菌和金黄色葡萄球菌对MC3T3-E1细胞系具有良好的细胞相容性作用。这项研究提出了一种简单有效的方法，可将抗菌剂和抗氧化剂掺入HA涂层中以修饰金属植入物表面。