Abstract The potential of methanolic leaves extract of H. elasticus in the mitigation of ulcer and inflammation was evaluated in this work. Ethanol and pylorus ligation induced rats were used for the screening of ulcer, whereas the anti-inflammatory activity against acute and chronic phases of inflammation was screened using carrageenan-induced paw edema and cotton pellet induced granuloma in rats. The H. elasticus (200 and 400 mg/kg p.o.) was administered to the ethanol and pylorus ligation induced rats. Gastric volume, pH, free acidity and total acidity were estimated in pylorus ligation induced ulcers of rats. Treatment with H. elasticus showed a reduction in ulcer index against ethanol and pylorus ligation induced ulcerations. The antiulcer activity may be due to the antisecretory and cytoprotective effects of the extract. Moreover, it also showed a highly significant (P ≤ 0.001) reduction in carrageenan and cotton pellet induced inflammations. This investigation suggests that H. elasticus leaves possess anti-inflammatory activity and promotes ulcer protection.

中文翻译：

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探索印度槲寄生 Helicantes elasticus (Desv.) 甲醇叶提取物的抗溃疡和抗炎活性

摘要 在这项工作中评估了弹性松的甲醇叶提取物在减轻溃疡和炎症方面的潜力。乙醇和幽门结扎诱导的大鼠被用于筛选溃疡，而使用角叉菜胶诱导的爪水肿和棉球诱导的大鼠肉芽肿筛选针对炎症的急性和慢性期的抗炎活性。H.elasticus (200 和 400 mg/kg po) 被给予乙醇和幽门结扎诱导的大鼠。在幽门结扎诱导的大鼠溃疡中评估胃体积、pH、游离酸度和总酸度。用H.elasticus 治疗显示针对乙醇和幽门结扎诱导的溃疡的溃疡指数降低。抗溃疡活性可能是由于提取物的抗分泌和细胞保护作用。而且，它还显示出非常显着（P ≤ 0.001）减少角叉菜胶和棉球引起的炎症。这项调查表明，弹性松树叶具有抗炎活性并促进溃疡保护。