Liver metastasis causes nearly half of death from solid tumors. Metastatic lesions, to the liver in particular, can become detectable years or decades after primary tumor removal, leaving an uncertain long-term prognosis in patients. Prostate cancer (PCa), a prominent metastatic dormant cancer, has the worst prognosis when found in the liver compared to other metastatic sites. These metastatic nodules display a therapy resistance in the liver pro-metastatic microenvironment; the resistance appears to be conferred by both dormancy and independent of dormancy when the nodules emerge. Within the review, the molecular underpinnings of how the liver aids and protects PCa cells seeding, colonization and resistance will be discussed.

肝转移导致近一半的实体瘤死亡。转移性病变，特别是肝脏的转移性病变，在原发性肿瘤切除数年或数十年后可能会变得可检测到，从而给患者留下不确定的长期预后。前列腺癌 (PCa) 是一种突出的转移性休眠癌症，与其他转移部位相比，在肝脏中发现时预后最差。这些转移性结节在肝脏前转移微环境中显示出治疗抗性；当结节出现时，抵抗力似乎是由休眠和独立于休眠赋予的。在综述中，将讨论肝脏如何帮助和保护 PCa 细胞播种、定植和抗性的分子基础。