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Biosynthesis of copperoxide nanoparticles using Abies spectabilis plant extract and analyzing its antinociceptive and anti-inflammatory potency in various mice models
Arabian Journal of Chemistry ( IF 5.3 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.arabjc.2020.07.006
Hongtao Liu , SiMin Zheng , HongFei Xiong , Mona S Alwahibi , Xiaoli Niu

Abstract Nanotechnology has shown rapid progress in various fields had made a remarkable change in the field of therapeutics too. The present study aims to synthesize and characterize the eco-friendly biocompatible copper oxide nanoparticles using Abies spectabilis plant extract (AS-CuONPs) and inspect its ameliorative potential against the different stimuli induced nociception and inflammatory reactions in mice. The formulated AS-CuONPs were characterized via the UV–vis spectroscopy, FT-IR, and TEM analysis. The nociception was induced by the method of acetic acid, glutamate, capsaicin, formalin, and thermal-induced techniques. The anti-inflammatory property of AS-CuONPs with carrageenan induced paw edema, peritoneal leukocyte infiltration, and carrageenan induced air pouch tests. Our result of UV–Visible spectroscopic analysis confirms the formation of AS-CuONPs and the characterization with FTIR and TEM proves the same. The result of various stimuli induced nociception models provide the evidence that formulated AS-CuONPs effectively inhibits the nociceptive responses in mice. Further the infiltration of leukocytes and inflammatory cytokines were drastically decreased by the AS-CuONPs treatment in the mice. The open field analysis confirms that the AS-CuONPs doesn’t impart any behavioral changes in mice. Over all our results confirms that AS-CuONPs is effective against different stimuli induced nociception and it act as a potent anti-inflammatory agent without rendering any side effects.

中文翻译:

使用冷杉植物提取物生物合成氧化铜纳米颗粒并分析其在各种小鼠模型中的镇痛和抗炎效力

摘要 纳米技术在各个领域的飞速发展也使治疗学领域发生了显着的变化。本研究旨在使用冷杉植物提取物 (AS-CuONPs) 合成和表征生态友好的生物相容性氧化铜纳米粒子,并检查其对小鼠不同刺激引起的伤害感受和炎症反应的改善潜力。通过紫外-可见光谱、FT-IR 和 TEM 分析表征配制的 AS-CuONP。伤害感受是通过醋酸、谷氨酸盐、辣椒素、福尔马林和热诱导技术的方法诱导的。AS-CuONPs 与角叉菜胶诱导的爪水肿、腹膜白细胞浸润和角叉菜胶诱导的气囊试验的抗炎特性。我们的紫外-可见光谱分析结果证实了 AS-CuONPs 的形成,FTIR 和 TEM 的表征也证明了这一点。各种刺激诱导的伤害感受模型的结果提供了配制 AS-CuONPs 有效抑制小鼠伤害感受反应的证据。此外,通过 AS-CuONPs 治疗小鼠,白细胞和炎性细胞因子的浸润显着减少。开放场分析证实 AS-CuONPs 不会给小鼠带来任何行为变化。总的来说,我们的结果证实 AS-CuONPs 对不同刺激引起的伤害感受有效,并且它作为一种有效的抗炎剂而不会产生任何副作用。各种刺激诱导的伤害感受模型的结果提供了配制 AS-CuONPs 有效抑制小鼠伤害感受反应的证据。此外,通过 AS-CuONPs 治疗小鼠,白细胞和炎性细胞因子的浸润显着减少。开放场分析证实 AS-CuONPs 不会给小鼠带来任何行为变化。总的来说,我们的结果证实 AS-CuONPs 对不同刺激引起的伤害感受有效,并且它作为一种有效的抗炎剂而不会产生任何副作用。各种刺激诱导的伤害感受模型的结果提供了配制 AS-CuONPs 有效抑制小鼠伤害感受反应的证据。此外,通过 AS-CuONPs 治疗小鼠,白细胞和炎性细胞因子的浸润显着减少。开放场分析证实 AS-CuONPs 不会给小鼠带来任何行为变化。总的来说,我们的结果证实 AS-CuONPs 对不同刺激引起的伤害感受有效,并且它作为一种有效的抗炎剂而不会产生任何副作用。开放场分析证实 AS-CuONPs 不会给小鼠带来任何行为变化。总的来说,我们的结果证实 AS-CuONPs 对不同刺激引起的伤害感受有效,并且它作为一种有效的抗炎剂而不会产生任何副作用。开放场分析证实 AS-CuONPs 不会给小鼠带来任何行为变化。总的来说,我们的结果证实 AS-CuONPs 对不同刺激引起的伤害感受有效,并且它作为一种有效的抗炎剂而不会产生任何副作用。
更新日期:2020-09-01
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