Osteoarthritis (OA) is a degenerative joint disease of the articular cartilage with subchondral bone remodeling and synovial inflammation. There is currently no cure for OA, making effective management extremely challenging. During the last years, significant advances has been made to develop regenerative medicine based on the use of stem cells as alternative for treating OA. Because of their several advantages including availability, expandability, transplantability, and ethical implications. mesenchymal stem/stromal cells (MSCs) appear thus to be a promising tool for the field. Based on the recent paper of Klemen Čamernik et al. in Stem Cell Reviews and Reports, we highlighted some challenges and possible strategies to enhance the therapeutic potential of MSCs for OA.

中文翻译：

---

间充质干细胞/间质细胞和骨关节炎：合并最新突破的时间。

骨关节炎（OA）是关节软骨的退行性关节疾病，伴有软骨下骨重塑和滑膜炎症。目前尚无OA的治愈方法，这使得有效管理极具挑战性。在过去的几年中，基于干细胞作为治疗OA的替代品，再生医学的开发取得了重大进展。由于它们的几个优点，包括可用性，可扩展性，可移植性和道德影响。间充质干/基质细胞（MSCs）似乎是该领域的有前途的工具。基于KlemenČamernik等人的最新论文。在《干细胞评论与报告》中，我们重点介绍了增强MSC对OA的治疗潜力的一些挑战和可能的策略。