After the introduction of the glymphatic system hypothesis, an increasing number of studies on cerebrospinal fluid and interstitial fluid dynamics within the brain have been investigated and reported. A series of diseases are known which develop due to abnormality of the glymphatic system including Alzheimer’s disease, traumatic brain injury, stroke, or other disorders. These diseases or disorders share the characteristics of the glymphatic system dysfunction or other mechanisms related to the interstitial fluid dynamics. In this review article, we propose “Central Nervous System (CNS) Interstitial Fluidopathy” as a new concept encompassing diseases whose pathologies are majorly associated with abnormal interstitial fluid dynamics. Categorizing these diseases or disorders as “CNS interstitial fluidopathies,” will promote the understanding of their mechanisms and the development of potential imaging methods for the evaluation of the disease as well as clinical methods for disease treatment or prevention. In other words, having a viewpoint of the dynamics of interstitial fluid appears relevant for understanding CNS diseases or disorders, and it would be possible to develop novel common treatment methods or medications for “CNS interstitial fluidopathies.”

在引入淋巴系统假说之后，越来越多的关于脑内脑脊液和间质流体动力学的研究被调查和报道。已知由于淋巴系统的异常而发展的一系列疾病，包括阿尔茨海默氏病、外伤性脑损伤、中风或其他病症。这些疾病或病症具有淋巴系统功能障碍或与间质流体动力学相关的其他机制的特征。在这篇综述文章中，我们提出“中枢神经系统 (CNS) 间质性流体病”作为一个新概念，涵盖其病理学主要与异常间质性流体动力学相关的疾病。将这些疾病或病症归类为“CNS 间质性液体病，”将促进对其机制的理解和开发用于评估疾病的潜在成像方法以及用于疾病治疗或预防的临床方法。换句话说，对间质液动力学的观点似乎与理解中枢神经系统疾病或病症相关，并且有可能开发出针对“中枢神经系统间质性液病”的新型通用治疗方法或药物。