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Effect of Rat Exposure to Moderate Pressure Oxygen Atmosphere on Resistance of Erythrocytes against Hemolysis
Bulletin of Experimental Biology and Medicine ( IF 0.9 ) Pub Date : 2020-06-01 , DOI: 10.1007/s10517-020-04850-5
O S Izmest'eva 1 , L A Dzikovskaya 1 , L P Zhavoronkov 1
Affiliation  

Exposure of male Wistar rats to oxygen atmosphere at moderate pressure (1.10-1.15 atm) for 4 h resulted in significant, transient, and reversible decrease in hemolytic resistance of peripheral blood erythrocytes. In 2 days after oxygen exposure, the bone marrow released young erythrocytes with enhanced hemolytic resistance as a compensation for oxygen injury. These findings suggest that normobaric oxygen load can be viewed as a stress factor of moderate intensity.

中文翻译:

大鼠暴露于中压氧气环境对红细胞抗溶血能力的影响

雄性 Wistar 大鼠在中等压力 (1.10-1.15 atm) 的氧气环境中暴露 4 小时,导致外周血红细胞溶血阻力显着、短暂和可逆的降低。在氧气暴露后2天,骨髓释放具有增强溶血性的年轻红细胞作为氧损伤的补偿。这些发现表明,常压氧负荷可被视为中等强度的压力因素。
更新日期:2020-06-01
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