Demands for certified reference materials of osmium mono-element standard solutions are increasing to obtain reliable results in chemical instrument analyses. The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) issues the Guideline for Elemental Impurities (Q3D) and lists osmium as an elemental impurity to be measured. There are few reports on osmium standards although osmium is widely used as a catalyst and needed to measure. In the present paper, potential titration paths were explored to determine the mass fraction of osmium traceable to the International System of Units. Three stoichiometric reactions were examined to assay osmium compounds, and the availability was discussed. The presented discussions will contribute to establish first osmium mono-element standard solutions characterized by a metrologically valid procedure.

中文翻译：

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分析锇化合物的潜在滴定路径的考虑：建立单元素标准溶液

为了在化学仪器分析中获得可靠的结果，对锇单元素标准溶液的有证标准物质的需求不断增加。国际人用药品技术要求协调委员会 (ICH) 发布了元素杂质指南 (Q3D)，并将锇列为要测量的元素杂质。尽管锇被广泛用作催化剂并需要测量，但关于锇标准的报道很少。在本文中，探索了潜在的滴定路径，以确定可追溯到国际单位制的锇的质量分数。检查了三种化学计量反应来测定锇化合物，并讨论了可用性。