The currently available data with respect to the association between vitamin D receptor (VDR) gene polymorphism and risk to urolithiasis are inconclusive and inconsistent. Hence, an exhaustive meta-analysis can solve the discrepancies and provide a hint for upcoming investigations. Herein, a meta-analysis was carried out to attain a conclusive estimate of the association between VDR gene single nucleotide polymorphisms (SNPs) and urolithiasis risk. The major databases, including ISI Web of science, Scopus, and PubMed/MEDLINE were searched systematically from until June 2020 to retrieve all relevant studies. Association between VDR gene polymorphisms, including FokI (rs2228570), TaqI (rs731236), BsmI (rs1544410), and ApaI (rs7975232), and urolithiasis risk was evaluated using pooled odds ratio (OR) and their corresponding 95% confidence interval (CI). Additionally, to seek for the potential source of heterogeneity, meta-regression analyses were exerted. Literature search led to finally finding of 33 studies evaluating the VDR gene SNPs and urolithiasis risk. It was observed that none of the four SNPs were significantly associated with urolithiasis predisposition. However, subgroup analysis confirmed higher risk of urolithiasis in East-Asian and Caucasian population with ApaI and TaqI gene polymorphism. The analyses of sensitivity acknowledged the results stability. Although this meta-analysis did not support the association of FokI, TaqI, BsmI, and ApaI in the overall polled analysis, it suggests that ApaI and TaqI SNPs is associated with increased risk of urolithiasis in East-Asian and Caucasians populations.

中文翻译：

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维生素 D 受体基因多态性和尿石症易感性：荟萃回归和荟萃分析。


目前关于维生素 D 受体 (VDR) 基因多态性与尿石症风险之间关系的现有数据尚无定论且不一致。因此，详尽的荟萃分析可以解决差异，并为即将进行的调查提供线索。在此，进行荟萃分析以获得 VDR 基因单核苷酸多态性 (SNP) 与尿石症风险之间关联的结论性估计。截至 2020 年 6 月，对主要数据库（包括 ISI Web of science、Scopus 和 PubMed/MEDLINE）进行了系统检索，以检索所有相关研究。使用合并比值比 (OR) 及其相应的 95% 置信区间 (CI) 评估 VDR 基因多态性（包括 FokI (rs2228570)、TaqI (rs731236)、BsmI (rs1544410) 和 ApaI (rs7975232)）与尿石症风险之间的关联。此外，为了寻找异质性的潜在来源，进行了荟萃回归分析。文献检索最终找到了 33 篇评估 VDR 基因 SNP 与尿石症风险的研究。据观察，这四个 SNP 中没有一个与尿石症易感性显着相关。然而，亚组分析证实，具有 ApaI 和 TaqI 基因多态性的东亚和高加索人群患尿石症的风险较高。敏感性分析确认了结果的稳定性。尽管该荟萃分析不支持总体民意调查分析中 FokI、TaqI、BsmI 和 ApaI 的关联，但表明 ApaI 和 TaqI SNP 与东亚和白种人人群尿石症风险增加相关。