Working memory (WM) – one of the brain ability that maintains information – can evaluate the function of brain. Activities related to memory sustention, inhibition and disinhibition have gathered significant attention for the basic neurocognitive architecture. Although researchers have proposed some brain models that attempt to explain the entire procedure of WM, little evidence can proof and describe it, and more particularly, regions and structures of maintenance, inhibition and disinhibition require more investigation. We used phase lock coherence and general partial directed coherence to construct connections among four adaptively fitted EEG sources, and we also applied previous published models to describe the brain circuits of maintenance, inhibition and disinhibition. Referring to a classical visual n-back paradigm, we recruited forty five mental health undergraduates in this experiment. We found that the bilateral prefrontal cortex (PFC) mainly focused on some cognitive components, for example, rehearsal before recognition to classify objects, inhibition to maintain positive memory and activities, and disinhibition to arouse or activate subsequent interactions in brain. Meanwhile, the right PFC sometimes could assist left PFC to implement high capacity WM tasks. By contrast, the posterior regions, PPC, tends to be engaged in attention arousing and maintaining. These two findings suggest that a) the recurrent maintenance circuit may keep the brain executing positive cognitive components, b) then the instantly monitoring inhibition would pause the deadlocked sustention function to save energy, and c) the arriving of disinhibition arouses the next step in brain to select new subject or focus on novel subjects.

中文翻译：

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在工作记忆中维持，抑制和解除抑制的大脑网络。

工作记忆（WM）是维持信息的大脑能力之一，可以评估大脑的功能。与记忆维持，抑制和解除抑制有关的活动已引起了对基本神经认知结构的极大关注。尽管研究人员提出了一些大脑模型来试图解释WM的整个过程，但几乎没有证据可以证明和描述WM，尤其是维持，抑制和解除抑制的区域和结构需要更多的研究。我们使用了锁相干和一般的部分有向相干来构造四个自适应拟合的脑电信号源之间的连接，并且我们还使用了以前发表的模型来描述维持，抑制和去抑制的大脑回路。提到经典的视觉n-back范式，在这项实验中，我们招募了45名心理健康专业的本科生。我们发现，双侧前额叶皮层（PFC）主要集中在一些认知成分上，例如，在识别之前对对象进行排练以对对象进行分类，抑制以保持积极的记忆和活动，以及抑制去激发或激活大脑中的后续相互作用。同时，右PFC有时可以协助左PFC执行大容量WM任务。相反，后部区域PPC倾向于引起注意力和保持注意力。这两个发现表明，a）循环维持电路可能使大脑执行积极的认知成分，b）即时监视抑制将使僵持的维持功能暂停以节省能量，