Introduction:

This study tried to find out type of lobar features found in patients with progressive supranuclear palsy (PSP) and whether they differ from those of frontotemporal dementia (FTD) as both of these are tauopathies.

Methods:

We studied lobar functions of 45 patients with PSP.

Results:

Five (11.1%) patients had no lobar feature; 11 (24.4%) had PSP-like features like apathy, frontal release signs, impaired motor Luria written sequences, and fist-edge-palm test; and 29 (64.4%) patients had FTD-like lobar features like disinhibition, poor naming, and word finding difficulty. Among features resembling FTD, behavioural variant type occurred in 31.1%, primary progressive aphasia type occurred in 58.6%, 3.4% patients had semantic dementia type features, and 6.9% were unclassified.

Conclusions:

Hence, patients with PSP with lobar features may fall in the middle of PSP-FTD spectrum with frontal lobe features typical of PSP (PSP-frontal like) and those with frontal lobe features resembling FTD (PSP-FTD complex) in between.

中文翻译：

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PSP-FTD 复合体：PSP 的可能变体。

 介绍：

本研究试图找出进行性核上性麻痹 (PSP) 患者的脑叶特征类型，以及它们是否与额颞叶痴呆 (FTD) 患者不同，因为这两种疾病都是 tau蛋白病。

 方法：

我们研究了 45 名 PSP 患者的脑叶功能。

 结果：

5 名（11.1%）患者没有肺叶特征； 11 名 (24.4%) 具有类似 PSP 的特征，如冷漠、额叶释放迹象、运动性 Luria 书写序列受损和拳头手掌测试； 29 名 (64.4%) 患者具有类似 FTD 的脑叶特征，如抑制解除、命名不当和找词困难。在类似FTD的特征中，行为变异型占31.1%，原发性进行性失语型占58.6%，3.4%患者有语义痴呆型特征，6.9%未分类。

 结论：

因此，具有脑叶特征的 PSP 患者可能位于 PSP-FTD 谱系的中间，其中典型的 PSP 额叶特征（PSP-额叶样）和额叶特征类似于 FTD（PSP-FTD 复合体）的患者介于两者之间。