Background: The resistance of glioma patients to temozolomide (TMZ) treatment is a limiting factor in clinical treatment. Circular RNA HIPK3 (circ-HIPK3) was found to be highly expressed in glioma, however, the role and potential mechanism of exosomal circ-HIPK3 from TMZ-resistant cells remain poorly unclear.

中文翻译：

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外泌体 circ-HIPK3 通过调节胶质瘤中的 miR-421/ZIC5 轴促进肿瘤进展和替莫唑胺耐药

背景：胶质瘤患者对替莫唑胺（TMZ）治疗的耐药性是临床治疗的限制因素。发现环状 RNA HIPK3 (circ-HIPK3) 在胶质瘤中高表达，然而，来自 TMZ 抗性细胞的外泌体 circ-HIPK3 的作用和潜在机制仍不清楚。