Selective breeding is a continued element of both crop and livestock breeding since early prehistory. In this work, we are proposing a new web-based simulation framework ("MoBPSweb") that is combining a unified language to describe breeding programs with the simulation software MoBPS, standing for 'Modular Breeding Program Simulator'. Thereby, MoBPSweb is providing a flexible environment to enter, simulate, evaluate and compare breeding programs. Inputs can be provided via modules ranging from a Vis.js-based flash environment for "drawing" the breeding program to a variety of modules to provide phenotype information, economic parameters and other relevant information. Similarly, results of the simulation study can be extracted and compared to other scenarios via output modules (e.g. observed phenotypes, accuracy of breeding value estimation, inbreeding rates). Usability of the framework is showcased along a toy example of a dairy cattle breeding program on farm level, with comparing scenarios differing in implemented breeding value estimation, selection index and selection intensity being considered. Comparisons are made considering both short and long-term effects of the different scenarios in terms of genomic gains, rates of inbreeding and the accuracy of the breeding value estimation. Lastly, general applicability of the MoBPSweb framework and the general potential for simulation studies for genetics and in particular in breeding are discussed.

中文翻译：

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MoBPSweb：基于网络的框架，用于模拟和比较育种程序

自史前早期以来，选择性育种一直是农作物和家畜育种的持续要素。在这项工作中，我们提出了一个新的基于Web的仿真框架（“ MoBPSweb”），该框架结合了用于描述育种程序的统一语言和仿真软件MoBPS，代表了“模块化育种程序模拟器”。从而，MoBPSweb提供了一个灵活的环境来输入，模拟，评估和比较育种程序。可以通过从基于Vis.js的Flash环境（用于“绘制”育种程序的）模块到提供表型信息，经济参数和其他相关信息的各种模块等模块提供输入。同样，可以通过输出模块（例如观察到的表型，繁殖价值估算的准确性，近交率）。通过在农场一级奶牛育种计划的一个玩具示例中展示了该框架的可用性，并比较了在实施的育种价值估算，考虑的选择指数和选择强度方面不同的方案。根据基因组增益，近交率和育种价值估算的准确性，考虑了不同情景的短期和长期影响进行了比较。最后，讨论了MoBPSweb框架的一般适用性以及遗传学特别是育种中模拟研究的一般潜力。比较实施的育种值估算方法不同的方案，考虑选择指标和选择强度。根据基因组增益，近交率和育种价值估算的准确性，考虑了不同情景的短期和长期影响进行了比较。最后，讨论了MoBPSweb框架的一般适用性以及遗传学特别是育种中模拟研究的一般潜力。比较实施的育种值估算方法不同的方案，考虑选择指标和选择强度。根据基因组增益，近交率和育种价值估算的准确性，考虑了不同情景的短期和长期影响进行了比较。最后，讨论了MoBPSweb框架的一般适用性以及遗传学特别是育种中模拟研究的一般潜力。