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A randomized controlled trial to investigate safety and variability of egg excretion after repeated controlled human hookworm infection.
The Journal of Infectious Diseases ( IF 5.0 ) Pub Date : 2020-07-10 , DOI: 10.1093/infdis/jiaa414 Marie-Astrid Hoogerwerf 1 , Jan Pieter R Koopman 1 , Jacqueline J Janse 1 , Marijke C C Langenberg 1 , Roos van Schuijlenburg 1 , Yvonne C M Kruize 1 , Eric A T Brienen 1 , Mikhael D Manurung 1 , Petra Verbeek-Menken 2 , Martha T van der Beek 3 , Inge M Westra 4 , Pauline Meij 4 , Leo G Visser 2 , Lisette van Lieshout 1 , Sake J de Vlas 5 , Maria Yazdanbakhsh 1 , Luc E Coffeng 5 , Meta Roestenberg 1, 2
The Journal of Infectious Diseases ( IF 5.0 ) Pub Date : 2020-07-10 , DOI: 10.1093/infdis/jiaa414 Marie-Astrid Hoogerwerf 1 , Jan Pieter R Koopman 1 , Jacqueline J Janse 1 , Marijke C C Langenberg 1 , Roos van Schuijlenburg 1 , Yvonne C M Kruize 1 , Eric A T Brienen 1 , Mikhael D Manurung 1 , Petra Verbeek-Menken 2 , Martha T van der Beek 3 , Inge M Westra 4 , Pauline Meij 4 , Leo G Visser 2 , Lisette van Lieshout 1 , Sake J de Vlas 5 , Maria Yazdanbakhsh 1 , Luc E Coffeng 5 , Meta Roestenberg 1, 2
Affiliation
Controlled human hookworm infections could significantly contribute to the development of a hookworm vaccine. However, current models are hampered by low and unstable egg output, reducing generalizability and increasing sample sizes. This study aims to investigate the safety, tolerability and egg output of repeated exposure to hookworm larvae.
中文翻译：
一项随机对照试验，旨在调查反复受控人钩虫感染后卵子排泄的安全性和可变性。
受控的人类钩虫感染可以显着促进钩虫疫苗的开发。然而，当前的模型受到产蛋量低且不稳定的阻碍，降低了普遍性并增加了样本量。本研究旨在调查反复接触钩虫幼虫的安全性、耐受性和产卵量。
更新日期：2020-07-10
中文翻译：
一项随机对照试验，旨在调查反复受控人钩虫感染后卵子排泄的安全性和可变性。
受控的人类钩虫感染可以显着促进钩虫疫苗的开发。然而，当前的模型受到产蛋量低且不稳定的阻碍，降低了普遍性并增加了样本量。本研究旨在调查反复接触钩虫幼虫的安全性、耐受性和产卵量。
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