The dynamics of rare X-linked recessive traits is explored by simulation. The model follows the prevalence of affected males and carrier females as separate but correlated variables. Different mutation rates and selection coefficients are introduced for males and females. A virtual population based on a published study of hemophilia B in the west of Scotland is followed at weekly intervals over many years. Speculative values of critical parameters to mimic the real population are proposed.

中文翻译：

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血友病 B — 突变率和发病率 — 模拟研究

通过模拟探索了罕见的 X 连锁隐性性状的动力学。该模型将受影响的男性和携带者女性的患病率作为独立但相关的变量。为男性和女性引入了不同的突变率和选择系数。基于已发表的苏格兰西部血友病 B 研究的虚拟人群，多年来每周都会被跟踪。提出了模拟真实人口的关键参数的推测值。