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Confirming the geography of fatty infiltration in the deep cervical extensor muscles in whiplash recovery.
Scientific Reports ( IF 3.8 ) Pub Date : 2020-07-10 , DOI: 10.1038/s41598-020-68452-x
Andrew C Smith 1 , Stephanie R Albin 1 , Rebecca Abbott 2, 3 , Rebecca J Crawford 4 , Mark A Hoggarth 2, 5 , Marie Wasielewski 2 , James M Elliott 2, 6
Affiliation  

Previous preliminary work mapped the distribution of neck muscle fat infiltration (MFI) in the deep cervical extensor muscles (multifidus and semispinalis cervicis) in a small cohort of participants with chronic whiplash associated disorders (WAD), recovered, and healthy controls. While MFI was reported to be concentrated in the medial portion of the muscles in all participants, the magnitude was significantly greater in those with chronic WAD. This study aims to confirm these results in a prospective fashion with a larger cohort and compare the findings across a population of patients with varying levels of WAD-related disability one-year following the motor vehicle collision. Sixty-one participants enrolled in a longitudinal study: Recovered (n = 25), Mild (n = 26) and Severe WAD (n = 10) were studied using Fat/Water magnetic resonance imaging, 12-months post injury. Bilateral measures of MFI in four quartiles (Q1–Q4; medial to lateral) at cervical levels C4 through C7 were included. A linear mixed model was performed, controlling for covariates (age, sex, body mass index), examining interaction effects, and comparing MFI distribution between groups. The recovered group had significantly less MFI in Q1 compared to the two symptomatic groups. Group differences were not found in the more lateral quartiles. Results at 12 months are consistent with the preliminary study, indicating that MFI is spatially concentrated in the medial portions of the deep cervical extensors regardless of WAD recovery, but the magnitude of MFI in the medial portions of the muscles is significantly larger in those with severe chronic WAD.



中文翻译:

证实了鞭打恢复中深部宫颈伸肌脂肪浸润的地理特征。

先前的初步工作绘制了一小群患有慢性鞭打相关疾病(WAD),康复和健康对照的参与者的颈部深部伸肌(多裂肌和半棘半颈肌)中颈部肌肉脂肪浸润(MFI)的分布图。据报道,所有参与者中MFI都集中在肌肉的内侧部分,而慢性WAD患者的幅度明显更大。这项研究旨在以较大的队列研究以前瞻性的方式确认这些结果,并在一年后的机动车碰撞中,对不同水平的WAD相关残疾患者进行比较。六十一名参与者参加了一项纵向研究:使用脂肪/水磁共振成像研究了康复者(n = 25),轻度(n = 26)和严重WAD(n = 10),受伤后12个月。包括在C4至C7子宫颈水平的四个四分位数(Q1-Q4;内侧至外侧)中进行MFI的双边测量。进行线性混合模型,控制协变量(年龄,性别,体重指数),检查相互作用影响,比较各组之间的MFI分布。与两个症状组相比,康复组在第一季度的MFI明显更少。在更横向的四分位数中未发现组差异。12个月时的结果与初步研究一致,表明无论WAD恢复如何,MFI在空间上都集中在深颈伸肌的中间部分,但是在严重的肌肉中,M内侧的MFI幅度明显更大慢性WAD。包括从颈椎水平C4至C7的内侧到外侧。进行线性混合模型,控制协变量(年龄,性别,体重指数),检查相互作用影响,比较各组之间的MFI分布。与两个症状组相比,康复组在第一季度的MFI明显更少。在更横向的四分位数中未发现组差异。12个月时的结果与初步研究一致,表明无论WAD恢复如何,MFI在空间上都集中在深颈伸肌的中间部分,但是在严重的肌肉中,M内侧的MFI幅度明显更大慢性WAD。包括从颈椎水平C4至C7的内侧到外侧。进行线性混合模型,控制协变量(年龄,性别,体重指数),检查相互作用影响,并比较各组之间的MFI分布。与两个症状组相比,康复组在第一季度的MFI明显更少。在更横向的四分位数中未发现组差异。12个月时的结果与初步研究一致,表明无论WAD恢复如何,MFI在空间上都集中在深颈伸肌的中间部分,但是在严重的肌肉中,M内侧的MFI幅度明显更大慢性WAD。体重指数),检查交互作用以及比较各组之间的MFI分布。与两个症状组相比,康复组在第一季度的MFI明显更少。在更横向的四分位数中未发现组差异。12个月时的结果与初步研究一致,表明无论WAD恢复如何,MFI在空间上都集中在深颈伸肌的中间部分,但是在严重的肌肉中,M内侧的MFI幅度明显更大慢性WAD。体重指数),检查交互作用以及比较各组之间的MFI分布。与两个症状组相比,康复组在第一季度的MFI明显减少。在更多的四分位数中未发现组差异。12个月时的结果与初步研究一致,表明无论WAD恢复如何,MFI在空间上都集中在深颈伸肌的中间部分,但是在严重的肌肉中,M内侧的MFI幅度明显更大慢性WAD。

更新日期:2020-07-10
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