Cuticular drusen show some similarities to and differences from soft drusen in age-related macular degeneration (AMD) and might thus be a unique AMD subtype. Previous studies on cuticular drusen were performed mainly in white ethnic groups, but AMD shows ethnic differences. We investigated clinical manifestations of cuticular drusen in Korean patients to evaluate possible ethnic differences. Clinical records of Korean patients with cuticular drusen were retrospectively reviewed. Fundus distribution pattern, imaging features, and presence of large drusen, drusenoid pigment epithelial detachment (PED), and macular complications, including geographic atrophy (GA), choroidal neovascularization (CNV), and acquired vitelliform lesion (AVL), were assessed via multimodal imaging in 162 eyes with cuticular drusen (n = 81 patients; 67 females; mean age: 66.6 ± 9.1 years). Diffuse distribution was found in 61.7% and peripapillary involvement in 75.3% of eyes. Large drusen, drusenoid PED, GA, CNV, and AVL were observed in 59.3%, 26.5%, 18.5%, 3.7%, and 1.2% of eyes, respectively. The macular complication prevalence was similar between patients ≤ 60 and those > 60 years old. In Korean patients, cuticular drusen were less frequently associated with macular complications than in white patients, and the proportion of macular complications differed significantly, with AVL representing an uncommon complication.

表皮小疣在年龄相关性黄斑变性（AMD）中显示出与软性小疣相似或不同，因此可能是独特的AMD亚型。先前对表皮玻璃膜疣的研究主要在白人种族中进行，但AMD显示种族差异。我们调查了韩国患者表皮玻璃膜疣的临床表现，以评估可能的种族差异。回顾性分析韩国皮肤表皮疣患者的临床记录。通过多模式评估了眼底分布模式，影像学特征以及是否存在大的玻璃疣，玻璃疣样色素上皮脱离（PED）和黄斑并发症，包括地理萎缩（GA），脉络膜新血管形成（CNV）和后天性玻璃体病变（AVL） 162眼表皮玻璃膜疣的影像学检查（n = 81例； 67名女性；平均年龄：66岁）。6±9.1年）。61.7％的患者发现弥漫性分布，而75.3％的患者的乳头状周围受累。分别在59.3％，26.5％，18.5％，3.7％和1.2％的眼睛中观察到大的玻璃疣，类胡萝卜素PED，GA，CNV和AVL。≤60岁的患者和≥60岁的患者的黄斑并发症发生率相似。在韩国患者中，与白人患者相比，表皮玻璃膜疣与黄斑并发症的相关性较低，并且黄斑并发症的比例也存在显着差异，AVL代表一种罕见的并发症。≤60岁的患者和≥60岁的患者的黄斑并发症发生率相似。在韩国患者中，与白人患者相比，表皮玻璃膜疣与黄斑并发症的相关性较低，并且黄斑并发症的比例也有显着差异，AVL代表一种罕见的并发症。≤60岁的患者和≥60岁的患者的黄斑并发症发生率相似。在韩国患者中，与白人患者相比，表皮玻璃膜疣与黄斑并发症的相关性较低，并且黄斑并发症的比例也有显着差异，AVL代表一种罕见的并发症。