LC/MS-based chemical screening of culture extract led to a new highly oxygenated angucycline derivative, grecocycline D (1), from Streptomyces sp. KCB15JA014, isolated from a soil sample of Oedolgae in Jeju Island, Korea. The planar structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as HRESIMS and comparison with data from the literature. A relative and absolute configuration of 1 was assigned by ROESY experiment and electronic circular dichroism calculation. Compound 1 showed weak inhibitory activity against indoleamine 2,3-dioxygenase.

中文翻译：

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来自链霉菌属的高度氧化的金环素。KCB15JA014。

基于LC / MS的化学筛选培养物提取物，从链霉菌属（Streptomyces sp。）产生了一种新的高度氧化的古环素衍生物（grecocycline D（1））。KCB15JA014，从韩国济州岛的Oedolgae的土壤样品中分离得到。平面结构是根据光谱分析确定的，包括1D和2D NMR技术以及HRESIMS，并与文献数据进行了比较。通过ROESY实验和电子圆二色性计算，将相对和绝对构型分配为1。化合物1显示出对吲哚胺2，3-二加氧酶的弱抑制活性。