To investigate the role of circular RNA DLGAP4 (circDLGAP4) in lung cancer. circDLGAP4 expression was detected in lung cancer tissues and cell lines by PCR. The correlation between circDLGAP4 and clinicopathological characteristics of lung cancer patients was investigated. Moreover, the influences of depression of circDLGAP4 on the biological processes biological processes of lung cancer cells were explored in vitro. In addition, whether circDLGAP4 regulated lung cancer cell biological processes by sponging microRNA-143 (miR-143) to regulate cyclin-dependent kinase 1 (CDK1) expression was explored and verified in another lung cell line. CircDLGAP4 expression was remarkably elevated in lung cancer tissues and was significantly corrected with TNM stage and tumor metastasis. Suppression of circDLGAP4 inhibited the biological performances of lung cancer cells. Also, there was a negative regulatory relationship between circDLGAP4 and miR-143. Inhibition of miR-143 alleviated the influences of circDLGAP4 depression on lung cancer cell biological processes. Moreover, CDK1 was discovered as a target of miR-143, and miR-143 was involved in the process of lung cancer cell biological processes through targeting CDK1. Our findings reveal that circular RNA circDLGAP4 is involved in lung cancer development through modulating microRNA-143/CDK1 axis. circDLGAP4 may serve as a potential biomarker for the diagnosis or treatment of lung cancer.

研究环状 RNA DLGAP4 (circDLGAP4) 在肺癌中的作用。通过PCR检测肺癌组织和细胞系中circDLGAP4的表达。研究了circDLGAP4与肺癌患者临床病理特征的相关性。此外，体外探讨了抑制circDLGAP4对肺癌细胞生物学过程的影响。. 此外，在另一个肺细胞系中探索并验证了circDLGAP4是否通过海绵microRNA-143（miR-143）调节细胞周期蛋白依赖性激酶1（CDK1）表达来调节肺癌细胞生物学过程。CircDLGAP4 表达在肺癌组织中显着升高，并且随着 TNM 分期和肿瘤转移得到显着纠正。circDLGAP4 的抑制抑制了肺癌细胞的生物学性能。此外，circDLGAP4 和 miR-143 之间存在负调控关系。miR-143的抑制减轻了circDLGAP4抑制对肺癌细胞生物学过程的影响。此外，CDK1被发现是miR-143的靶点，miR-143通过靶向CDK1参与肺癌细胞生物学过程。我们的研究结果表明，环状 RNA circDLGAP4 通过调节 microRNA-143/CDK1 轴参与肺癌的发展。circDLGAP4 可作为肺癌诊断或治疗的潜在生物标志物。